The Framingham risk score underestimates the risk of cardiovascular events in the HER2-positive breast cancer population

Current Oncology
W LawSusan Dent

Abstract

Patients with breast cancer (bca) who overexpress her2 (the human epidermal growth factor receptor 2) are at risk for cardiotoxicity when treated with anthracycline-based chemotherapy and her2-targeted agents. The Framingham risk score (frs) is a validated tool that stratifies patients into high-, intermediate-, or low-risk groups and calculates their 10-year risk of developing cardiovascular disease (cvd) based on past medical history, systolic blood pressure, and measurement of serum lipids. We retrospectively analyzed patients with her2-positive bca to determine whether the frs predicts adverse cardiovascular (CV) events or cardiotoxicity in patients treated using anthracyclines or her2-targeted therapy, or both. The frs was determined for patients with bca referred to The Ottawa Hospital Cardiology-Oncology Clinic from October 2008 to August 2014. The patients were stratified into high (≥20%), intermediate (10%-20%), and low (<10%) 10-year cv risk groups. Primary outcomes included cvd-related hospitalizations and deaths, and cardiotoxicity [drop in left ventricular ejection fraction (lvef) of >10% to a lvef ≤50%]. Of the 152 patients included in the analysis (median follow-up: 40.7 months; range: 3.5-263 months), 47 (31%) w...Continue Reading

Citations

Mar 31, 2019·American Journal of Epidemiology·Roberta FloridoElizabeth Selvin
Feb 23, 2020·Journal of Cancer Survivorship : Research and Practice·Su-Min JeongJuhee Cho
Sep 7, 2020·European Journal of Heart Failure·Tochukwu M OkwuosaClyde W Yancy
Feb 5, 2019·Journal of the National Cancer Institute·Husam Abdel-QadirGeoffrey M Anderson
Nov 26, 2020·The International Journal of Cardiovascular Imaging·Huda El MaisGary R Small
Feb 25, 2021·European Journal of Preventive Cardiology·Juan Caro-CodónUNKNOWN CARDIOTOX registry investigators
Mar 13, 2021·Hipertensión y riesgo vascular·P Blanch GraciaP Armario
Jul 6, 2021·Heart, Lung & Circulation·Lloyd E Butel-SimoesAaron L Sverdlov

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