The Framingham Score and the Systematic Coronary Risk Evaluation at Low Cutoff Values Are Useful Surrogate Markers of High-risk Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis

The Journal of Rheumatology
Patrick H DesseinMiguel A Gonzalez-Gay

Abstract

We determined the performance of the Framingham score and the Systematic COronary Risk Evaluation (SCORE) in assessing high-risk atherosclerosis in patients with rheumatoid arthritis (RA). We assembled 330 cases without established cardiovascular disease (CVD), diabetes, and moderate or severe chronic kidney disease among 451 consecutive Spanish patients who underwent CVD risk screening and carotid ultrasound-determined plaque assessment. The findings were validated in 90 black and 97 white African patients. When sensitivity for the Framingham score was set at 80% in receiver-operator curve analysis [area under the curve (AUC) = 0.799], the corresponding cutoff value and specificity were 7.3% and 63%, respectively. At a specificity of 80%, the cutoff value and sensitivity were 10.8% and 65%, respectively. When sensitivity for SCORE (AUC = 0.747) was set at 80%, the cutoff value and specificity were 0.5% and 58%, respectively. At a specificity of 80%, the cutoff value and sensitivity were 1.5% and 50%, respectively. Upon applying a cutoff value of 7.3% for the Framingham and 0.5% for SCORE in African white patients with RA, the corresponding sensitivities and specificities were 67% and 72%, and 67% and 55%, respectively. CVD ris...Continue Reading

References

Aug 9, 2005·Seminars in Arthritis and Rheumatism·Miguel A Gonzalez-GayJavier Martin
Oct 29, 2005·Arthritis and Rheumatism·Inmaculada del RincónAgustín Escalante
Feb 4, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Adam D GepnerJames H Stein
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Mar 14, 2008·Seminars in Arthritis and Rheumatism·Carlos Gonzalez-JuanateyMiguel A Gonzalez-Gay
Nov 28, 2008·Arthritis and Rheumatism·J Antonio Aviña-ZubietaDiane Lacaille
Feb 10, 2011·Arthritis and Rheumatism·Matthew R EvansInmaculada del Rincón
Mar 3, 2012·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·Eric KlugUNKNOWN Lipid and Atherosclerosis Society of Southern Africa (LASSA)
Aug 13, 2013·Annals of the Rheumatic Diseases·Patrick H Dessein, Anne G Semb
Jul 6, 2014·Mediators of Inflammation·Patrick H DesseinGavin R Norton

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Citations

May 18, 2019·International Journal of Rheumatic Diseases·Hiroko YamamotoYasutomo Fujii
Sep 1, 2018·International Journal of Rheumatic Diseases·Martin I Wah-SuarezGuillermo Elizondo-Riojas
Aug 23, 2020·International Journal of Environmental Research and Public Health·Jéssica Alonso-MoleroJavier Llorca
Jul 4, 2018·Clinical Rheumatology·Martin I Wah-SuarezGuillermo Elizondo-Riojas
Mar 9, 2021·International Journal of Nephrology·Hon-Chun HsuPatrick H Dessein

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