The Frequencies of Immunosuppressive Cells in Adipose Tissue Differ in Human, Non-human Primate, and Mouse Models

Frontiers in Immunology
Ariane LaparraChristine Bourgeois

Abstract

Although the metabolic properties of white adipose tissue have been extensively characterized, the tissue's immune properties are now attracting renewed interest. Early experiments in a mouse model suggested that white adipose tissue contains a high density of regulatory T cells (Tregs), and so it was assumed that all adipose tissue has an immunosuppressive profile-even though the investigation was limited to visceral body fat in relatively old male mice. This observation was also corroborated by high frequencies of other cell subsets with immunoregulatory properties, such as anti-inflammatory M2 macrophages, and regulatory B cells. Many studies have since evidenced the persistence of pathogens (trypanosomes, Mycobacterium tuberculosis, HIV, etc.) in adipose tissue. However, a recent report identified adipose tissue as a reservoir of memory T cells capable of protecting animals upon rechallenge. The immune potential of lean adipose tissue thus remains to be further investigated. Here, we compared the relative proportions of immune cells (and Tregs in particular) in lean adipose tissue collected from humans, a non-human primate (the cynomolgus macaque), and three mouse models. We demonstrated that the proportion of Foxp3+ Tregs ...Continue Reading

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Citations

Feb 7, 2020·Animal : an International Journal of Animal Bioscience·B J Bradford, T H Swartz
Jun 17, 2020·Annual Review of Nutrition·Nishan Sudheera KalupahanaNaima Moustaid-Moussa
Jan 11, 2020·Frontiers in Microbiology·Christine BourgeoisOlivier Lambotte
Sep 4, 2020·Journal of Leukocyte Biology·Mingyong LiuSelene Meza-Perez
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Nov 7, 2021·Nature Reviews. Immunology·W V Trim, L Lynch

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Methods Mentioned

BETA
FACS
Fluorescence-Activated Cell Sorting
flow cytometry

Software Mentioned

Image J
GraphPad
FlowJo
GraphPad Prism

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