Oct 14, 1977

The frequency and distribution of sister chromatid exchanges in human chromosomes

Human Genetics
W F Morgan, P E Crossen


The distribution of sister chromatid exchanges (SCEs) both between and within chromosomes was studied in cultured human lymphocytes using the BRDU-Giemsa technique. In general, the distribution of SCEs between chromosomes was a function of chromosome length. However, chromosomes of the B group had more exchanges than expected on this basis, while the E, F, and G groups had less than expected. Analysis of cells showing both G-banding and sister chromatid differential staining indicates that the distribution of exchanges within the chromosomes is non-random and possible reasons for the observed distribution pattern are discussed.

Mentioned in this Paper

Lymphoid Cells
Chromosomes, Human
Chromosomes, Human,4-5
Autosome Abnormalities
Chromosomes, Human,19-20
Chromosomes, Human,16-18
Chromosomes, Human,21-22

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