The frequency of and risk factors for osteoporosis in Korean patients with rheumatoid arthritis

BMC Musculoskeletal Disorders
Joo-Hyun LeeSang-Cheol Bae

Abstract

The aim of this study was to investigate the prevalence of osteoporosis in rheumatoid arthritis (RA) patients and to analyze the risk factors in these patients using the KORean Observational study Network for Arthritis (KORONA) database. Among the RA patients in the KORONA who were recruited between July 2009 and December 2011, postmenopausal women with bone mineral density (BMD) results within one year from the time of KORONA enrollment were included in this study. The baseline characteristics of patients in three groups, defined by BMD results, were compared. The BMD measurement rates and prevalence of osteoporosis in the study patients were calculated in accordance with age and gender subgroups. Multivariable logistic regression analysis was used to explore the association between osteoporosis and demographics and disease-related risk factors. Of 1322 postmenopausal woman patients with RA in whom BMD was measured within one year of study enrollment, 619 patients (46.8 %) were in the osteoporosis group (T-score ≤ -2.5 SD). RA patients with osteoporosis had a higher frequency of previous fractures than those in other groups, especially fractures of the femur (p = 0.004) and wrist (p = 0.042). Advanced age (≥70 years; OR = 2.28...Continue Reading

References

Apr 1, 1996·British Journal of Rheumatology·A A Deodhar, A D Woolf
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T P Van StaaC Cooper
Nov 30, 2000·Arthritis Research·M Molokhia, P McKeigue
Oct 3, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D J van der VoortG J Dinant
Feb 26, 2004·Archives of Internal Medicine·Ragnhild E ØrstavikTore K Kvien
May 6, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John A KanisDan Mellstrom
May 26, 2004·Archives of Internal Medicine·Ethel S SirisMarc L Berger
Apr 26, 2007·Annals of the Rheumatic Diseases·M Güler-YükselW F Lems
Dec 24, 2008·Rheumatology International·J AizerM J Harrison
Dec 1, 2009·Autoimmunity Reviews·Gabriel J TobónAlain Saraux
Feb 4, 2010·Nature Reviews. Rheumatology·Juliet Compston
Oct 1, 2011·Zeitschrift für Rheumatologie·I HeberleinH Raspe
Jun 19, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M VisW F Lems
Nov 28, 2013·Current Opinion in Rheumatology·Arnd Kleyer, Georg Schett

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Citations

Feb 1, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V C KokG-D Hung
May 29, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yiping HuPeng Zhang
Jul 2, 2020·BMC Musculoskeletal Disorders·Zhuoran HuZhiming Lin
May 28, 2019·Current Rheumatology Reports·Giovanni Adami, Kenneth G Saag
Oct 11, 2020·Journal of Shoulder and Elbow Surgery·Michael A MovermanJonathan C Levy

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Methods Mentioned

BETA
X-ray
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SPSS

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