The frequency of cocaine administration impacts cocaine-induced receptor alterations

Brain Research
E M UnterwaldM Cuntapay

Abstract

The present study investigated the impact of dosing schedule on cocaine-induced receptor alterations. Rats were injected with 30 mg/kg per day of cocaine given either as a single injection or in two equally divided doses for 14 days. The effects of these two dosing regimens were compared with our previous findings following administration of cocaine three times daily at 1-h intervals. Using receptor autoradiography, twice daily injections of cocaine produced an upregulation of mu opioid receptors in the rostral nucleus accumbens, rostral caudate putamen, and layer I of the rostral cingulate cortex, whereas single daily injections resulted in a significant increase in the nucleus accumbens only. Only small insignificant increases in kappa opioid receptor densities were found following either once or twice daily cocaine injections, whereas three daily injections produced an increase in kappa receptor density in the cingulate cortex, nucleus accumbens, and caudate putamen. Increased dopamine D1 receptor binding was found in the nucleus accumbens and olfactory tubercle following twice daily cocaine injections, but not after single daily injections of the same total daily dose. These results demonstrate that the same total daily dos...Continue Reading

References

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Citations

Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Yong ZhangMary Jeanne Kreek
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Nicole M Avena, Bartley G Hoebel
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Stefan D SchlussmanMary Jeanne Kreek
Dec 9, 2003·Behavioural Brain Research·Tracie A PaineMary C Olmstead
Jun 5, 2003·Brain Research. Molecular Brain Research·Yan ZhouMary Jeanne Kreek
Oct 16, 2003·Brain Research. Molecular Brain Research·Shirzad JenabVanya Quinones-Jenab
Jul 20, 2002·Brain Research Bulletin·Eugene D FestaShirzad Jenab
Jul 20, 2002·Brain Research Bulletin·Shirzad JenabVanya Quinones-Jenab
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Mar 1, 2009·Journal of Addiction Medicine·Bartley G HoebelPedro Rada
Oct 20, 2012·BMC Pharmacology & Toxicology·Warren Winick-NgBettina E Kalisch
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Feb 7, 2014·Psychopharmacology·Natalie A Hadad, Lori A Knackstedt
Feb 22, 2014·Psychopharmacology·Stéphanie PuigFlorence Noble
Mar 29, 2002·Journal of Cellular Physiology·Michele Hummel, Ellen M Unterwald
Sep 3, 2013·Psychiatric Genetics·David A NielsenThomas R Kosten
May 1, 2012·Journal of Clinical Psychopharmacology·Erin N UmbergDavid J Greenblatt
Jun 28, 2015·Neuroscience and Biobehavioral Reviews·Florence AllainAnne-Noël Samaha
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Feb 7, 2015·Neuropharmacology·Caryne P CraigeEllen M Unterwald

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