The frequency of human papillomavirus detection in postmenopausal women on hormone replacement therapy

Gynecologic Oncology
E M SmithLubomir P Turek

Abstract

Postmenopausal women enrolled in the Iowa portion of the postmenopausal estrogen/progestin interventions randomized clinical trial (n = 105) during 1989-1991 were studied for (i) the prevalence of human papillomavirus (HPV) in this older age population (ages 45-64), and (ii) the association between hormone replacement therapies (HRTs) and changes in detection of HPV over a 2-year time period. HPV is causative in most cervical and some other genital cancers and in the presence of steroid hormones has been shown to increase neoplastic transformation by HPV in vitro. Using PCR to detect HPV DNA, the overall frequency of the virus regardless of time period was 50.3% (n = 53) with a baseline (BL) frequency of 38.1% and the second year follow-up (FU) of 22.9%. The oncogenic types HPV-16 (75.5%) and HPV-31 (20.8%) were the most commonly reported. All those with persistently detected infection (10.5%), defined as HPV+ at both BL and FU, were identified with HPV-16 or -18. Between these two time periods there were no significant differences in HPV frequency between the placebo and combined HRT groups (BL-/FU+, 21% vs 18%; BL+/FU-, 71% vs 80%). While the study is based on a small sample, the findings suggest that short-term use of HRTs i...Continue Reading

Associated Clinical Trials

References

Mar 18, 1992·Journal of the National Cancer Institute·M H Schiffman
Jan 1, 1992·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R KonnoA Yajima
May 15, 1990·International Journal of Cancer. Journal International Du Cancer·A HildesheimW E Rawls
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T CrookL Crawford
Sep 15, 1986·International Journal of Cancer. Journal International Du Cancer·L A BrintonR Hoover
Sep 1, 1993·Sexually Transmitted Diseases·H M BauerM M Manos

❮ Previous
Next ❯

Citations

Apr 20, 2000·Cytopathology : Official Journal of the British Society for Clinical Cytology·A Herbert
Sep 20, 2002·Sexually Transmitted Infections·M L ShewS Anderson
Aug 26, 2009·Journal of Women's Health·Keri N AlthoffPatti E Gravitt
Oct 1, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jennifer S SmithJeanne M Pimenta
May 12, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Ozgur AkbayirAhmet Gulkilik
Oct 20, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·E M SmithT H Haugen
Jul 20, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·E M SmithL P Turek
Mar 4, 1998·Current Opinion in Obstetrics & Gynecology·C W Burger, P Kenemans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.