The frequency of phospholipid antibodies in an unselected stroke population

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
L M MetzM J Fritzler

Abstract

Antibodies to cardiolipin and other phospholipids have been associated with recurrent thrombotic events, including stroke. Over a 16 month period we assessed an unselected cohort of 151 ischemic stroke patients for the presence of antiphospholipid antibodies. Patients with known systemic lupus erythematosis, systemic sclerosis, or Sjögrens Syndrome were excluded. Sera from patients admitted to hospital with a diagnosis of ischemic stroke (n = 151) and from controls (n = 111) assessed during the same period were tested for antiphospholipid antibodies (APLA) using 3 assays; anticardiolipin antibodies (ACA) by ELISA, prolonged activated partial thromboplastin time (APTT), and VDRL. The average age of ischemic stroke cases was 68 years (range 29 to 91) and of controls 63 years (range 29 to 86). The prevalence of APLA detected by at least one of the three methods was 12% for IS cases and 10% for controls. After correcting for known risk factors such as age, gender, diabetes mellitus, heart disease, hypertension, and smoking, the odds ratio for risk of stroke fell to 0.8 (C.I. 0.4 to 1.2). Our findings suggest that APLA may not be an independent risk factor for ischemic stroke in unselected persons who do not have known systemic lupu...Continue Reading

References

Dec 15, 1992·Annals of Internal Medicine·K S GinsburgM J Stampfer
Feb 1, 1992·Stroke; a Journal of Cerebral Circulation·P NenciniD Inzitari
Apr 1, 1991·Neurology·D C HessH A Rountree
Jun 1, 1991·Stroke; a Journal of Cerebral Circulation·J MontalbánG R Hughes
Feb 1, 1990·Stroke; a Journal of Cerebral Circulation·M J Kushner
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H P McNeilS A Krilis
Mar 1, 1989·Annals of Neurology·D P BrileyS H Goodnight
Jul 1, 1985·Clinical Immunology and Immunopathology·M J FritzlerT J Bowen
Aug 1, 1994·Clinical Immunology and Immunopathology·T Koike

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Citations

Jul 27, 2001·Current Rheumatology Reports·D Tanne, S Hassin-Baer
Mar 5, 2003·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Mark L Moster
Sep 10, 1998·Stroke; a Journal of Cerebral Circulation·D TanneS R Levine
Jun 1, 2000·Journal of Child Neurology·F J KirkhamV Ganesan
Apr 12, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wei Hsi ChenJia-Shou Liu
Jan 11, 2000·Stroke; a Journal of Cerebral Circulation·C D Bushnell, L B Goldstein
Jun 22, 2006·Cerebrovascular Diseases·Li-Ming LienChyi-Huey Bai
Aug 30, 2005·Annals of the New York Academy of Sciences·Giovanni SannaGraham R V Hughes
Oct 6, 2005·Journal of Thrombosis and Thrombolysis·Robin L Brey
May 9, 2009·Journal of Thrombosis and Haemostasis : JTH·S SaidiW Y Almawi
Jan 31, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wei Hsi ChenJia-Shou Liu
Nov 27, 2002·Clinical and Experimental Hypertension : CHE·Valeria CasoVirgilio Gallai
Oct 5, 2002·Stroke; a Journal of Cerebral Circulation·Robin L BreySteven J Kittner
Jul 13, 2002·Annals of the New York Academy of Sciences·Joab Chapman, Yehuda Shoenfeld
Dec 27, 2007·Yonsei Medical Journal·Penka A Atanassova
Jan 29, 1999·Hematology/oncology Clinics of North America·P Thiagarajan, S S Shapiro
Aug 2, 2006·Rheumatic Diseases Clinics of North America·Giovanni SannaMaria Jose Cuadrado

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