The frequency of resistant mutant virus before antiviral therapy

AIDS
R M RibeiroM A Nowak

Abstract

To calculate the expected prevalence of resistant HIV mutants before antiviral therapy. HIV replication generates virus mutants. The prevalence of these mutants is determined by mutation and selection/fitness. Some mutations will confer drug resistance and it is crucial for the success of antiviral drug therapy to determine whether these resistant viruses are present before the initiation of therapy. A quasispecies equation was used to calculate the expected frequency of drug-resistant virus prior to therapy. We show how the pretreatment frequency of resistant virus depends on the number of point mutations between wild-type and mutant virus, the selective disadvantage of the resistant mutant and the intermediate mutants, and the mutation rate.

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Citations

May 4, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alison L HillMartin A Nowak
Apr 24, 2007·Bulletin of Mathematical Biology·Libin RongAlan S Perelson
Jun 21, 2007·Bulletin of Mathematical Biology·O Krakovska, L M Wahl
Apr 30, 2013·Bio Systems·Faraimunashe Chirove, Edward M Lungu
Jul 24, 2003·Journal of Molecular Biology·Carlos BrionesCarmen Molina-París
Apr 21, 1999·Trends in Microbiology·P R Harrigan, C S Alexander
Sep 4, 2012·Nature Medicine·Daniel I S RosenbloomMartin A Nowak
Mar 29, 2007·Immunology and Cell Biology·Ruy M Ribeiro
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Jul 24, 2010·The Journal of Infectious Diseases·Sara Gianella, Douglas D Richman
Sep 21, 2010·AIDS Research and Human Retroviruses·Uma ShanmugasundaramBalakrishnan Pachamuthu
Apr 21, 2011·Current Opinion in HIV and AIDS·Rebecca F BaggaleyMarie-Claude Boily
Jul 20, 2006·Journal of the Royal Society, Interface·Christophe Fraser
Feb 29, 2000·Proceedings. Biological Sciences·D S CallawayM A Nowak
May 20, 2000·Proceedings. Biological Sciences·L M Wahl, M A Nowak
Sep 28, 2002·Proceedings. Biological Sciences·Sebastian BonhoefferRob J De Boer
Jan 20, 2004·Proceedings. Biological Sciences·Yoh IwasaMartin A Nowak
May 7, 2010·Science Translational Medicine·Libin RongAlan S Perelson
Jul 15, 2011·Science Translational Medicine·Lin ShenRobert F Siliciano
Dec 25, 2003·Journal of Virology·Jennifer A CollinsLouis Alexander
Sep 12, 2013·BMC Biology·Alan S Perelson, Ruy M Ribeiro
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Apr 26, 2006·Genetics·Yoh IwasaFranziska Michor
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·R M Ribeiro, S Bonhoeffer
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·R A ArnaoutM A Nowak
Jul 21, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M C ReM La Placa
Jun 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Stefany Moreno-GamezPleuni S Pennings
Jan 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael T BretscherSebastian Bonhoeffer
Mar 23, 2011·Journal of Theoretical Biology·Tinevimbo Shiri, Alex Welte

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