The Frequency of Signs of Meibomian Gland Dysfunction in Children with Epidermolysis Bullosa

Ophthalmology
Sophie M JonesKen K Nischal

Abstract

To determine the frequency of meibomian gland dysfunction (MGD) in children with epidermolysis bullosa (EB). Hospital-based cross-sectional study. One hundred five children with different forms of EB. Prospective ophthalmic examination of children with EB presenting over seventeen months including meibomian gland assessment using a recognized classification. Frequency of MGD. One hundred five children were recruited, 8.6% with junctional EB, 34.3% with simplex EB, 34.3% with autosomal recessive dystrophic EB, and 22.9% autosomal dominant dystrophic EB. Mean age was 7.42 years (range, 0.08-17.75 years). Ninety-two children (87.62%) demonstrated 1 or more features of MGD. Most children with EB exhibit signs of MGD. To the best of our knowledge, this is the first prospective ocular surface evaluation in children with EB to include lid margin evaluation using a recognized classification system. Our findings help explain some of the ocular surface anomalies seen in children with EB.

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Citations

Sep 5, 2018·Journal of Pediatric Ophthalmology and Strabismus·Wejdan Al-ThawabiehW Walker Motley
May 24, 2018·Orphanet Journal of Rare Diseases·Brendon W H LeeDedee F Murrell

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