The frequency of the A gamma T gene in the presence and absence of the beta S or beta C gene in the Black population of the Southeastern USA

Hemoglobin
T H Huisman, B Webber

Abstract

Quantitative information about the three types of gamma chains (A gamma T, A gamma I, G gamma) has been obtained for the Hb F from 285 normal Black babies, 172 babies with a Hb S or Hb C heterogeneity, and from 150 babies and older patients with the SS, SC, or CC conditions by means of a high pressure liquid chromatographic microprocedure. The frequency of the A gamma T gene in the AA babies was 0.1035, while that in the SS patients was a low 0.0362. This low A gamma T frequency in the SS population adequately explains the lower percentage (13.2%) of A gamma T heterozygotes among AS newborn babies as compared to 17.9% among AA babies. The genotype with the A gamma T mutant in trans to the beta S mutation is presumed to occur about three times more frequently than that in which the A gamma T mutant is in cis to the beta S mutation. A study of family members of one SS patients who has an A gamma T homozygosity provided data supporting linkage of the A gamma T and beta S anomalies in some Hb S heterozygotes.

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G SaglioS Ottolenghi
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R BernardsR A Flavell
Mar 15, 1979·Nature·P F LittleR Williamson
Feb 1, 1979·The Journal of Clinical Investigation·W A SchroederH Lam
Jan 1, 1977·Journal of Medicinal Chemistry·T H Althuis, H J Hess
Jan 1, 1980·American Journal of Hematology·T H Huisman, J B Wilson
Dec 12, 1959·Nature·K BETKEI SCHLICHT

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