The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study

Veterinary Dermatology
Andrew C SimpsonA Russell Moore

Abstract

Oclacitinib is a selective Janus kinase inhibitor for the treatment of canine allergic pruritus and atopic dermatitis in dogs. Glucocorticoids and ciclosporin increase urinary tract infection (UTI) frequency in dogs with inflammatory skin disease. Prospective study to evaluate the frequency of UTI and subclinical bacteriuria in dogs with allergic dermatitis receiving oclacitinib. Client-owned dogs ≥2 years of age with a history of allergic dermatitis without apparent history of urinary tract disease or predisposition to UTI were included. Prior to enrolment, urinalysis and quantitative urine culture were performed after a washout period of at least 14 days from systemic antimicrobial drugs and 28 days for ciclosporin and systemic glucocorticoids. Dogs received oclacitinib at labelled dosing for an intended period of 180-230 days with a follow-up urinalysis and urine culture performed regardless of urinary tract signs. Systemic antimicrobial and immune-modulating drugs were not administered during the study. None of the 55 dogs in this study developed UTI while receiving oclacitinib based on follow-up urinalysis and urine culture performed during a range of 58-280 days (mean 195 days). Two dogs developed self-limiting abnormal u...Continue Reading

References

Nov 1, 1977·The Journal of Small Animal Practice·A K KivistöM Sandholm
Aug 21, 1971·Lancet·J A CotterillL Bulusu
Dec 6, 2000·Journal of the American Animal Hospital Association·C R NorrisA L Ruby
Oct 8, 2003·Journal of Veterinary Internal Medicine·M Alexis SeguinJay F Levine
Jul 29, 2005·Journal of the American Veterinary Medical Association·Sheila M F TorresKim L Horne
Mar 16, 2007·The Journal of Small Animal Practice·C A PassmoreM R Stegemann
Oct 2, 2008·European Journal of Clinical Investigation·J Song, S N Abraham
Nov 14, 2012·Journal of the American Animal Hospital Association·Nicole SmeeGreg Grauer
Jan 18, 2013·Journal of the American Animal Hospital Association·Nicole SmeeGregory F Grauer
Feb 6, 2014·Journal of Veterinary Pharmacology and Therapeutics·A J GonzalesM Mitton-Fry
Jun 19, 2014·Journal of the American Veterinary Medical Association·Stephanie Y WanKatrina R Viviano
Dec 18, 2014·Current Opinion in Infectious Diseases·Valerie P O'BrienScott J Hultgren
Apr 1, 2015·The Veterinary Clinics of North America. Small Animal Practice·Shelly J Olin, Joseph W Bartges
Jul 3, 2015·Journal of Veterinary Internal Medicine·C WongJ L Westropp
Aug 4, 2016·The Veterinary Clinics of North America. Small Animal Practice·Shelly L Vaden, Jonathan Elliott

❮ Previous
Next ❯

Citations

Aug 22, 2020·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Julia Harrer, Roswitha Dorsch
Nov 15, 2021·Australian Veterinary Journal·H Teh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.