The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort

Gastroenterology Research and Practice
Marcin KrawczykIna Bergheim

Abstract

Introduction. The common adiponutrin (PNPLA3) variant p.Ile148Met is associated with liver injury. Here, we investigate the association of this polymorphism with hepatic and metabolic traits in a pediatric cohort. Patients and Methods. The study cohort comprised 142 German children (age 5-9 years, 98 overweight, 19 children with NAFLD). Results. Overweight children presented with increased serum ALT (P = 0.001) and GGT (P < 0.001) activities. ALT activities differed significantly (P = 0.02) between carriers of different PNPLA3 genotypes in the entire study cohort, in normal weight children (P = 0.02) and in children younger than 7 years (P = 0.02). Carriers of the prosteatotic PNPLA3 genotype p.148Met/Met displayed higher ALT activities as compared to children with the frequent genotype p.148Ile/Ile (P = 0.01). The BMI was however a stronger predictor of ALT activities compared to the PNPLA3 genotype (P < 0.001 and P = 0.06, resp.). The variant was associated with increased serum glucose levels (P = 0.01) and HOMA index (P = 0.02) in carriers of the p.148Ile/Met genotype but did not affect other metabolic traits or the presence of NAFLD. Discussion. The frequent PNPLA3 variant p.Ile148Met is associated with serum ALT activities...Continue Reading

References

Oct 13, 2006·Journal of Pediatric Gastroenterology and Nutrition·Heather M PattonJoel E Lavine
Jun 16, 2010·Journal of Hepatology·Stefano RomeoMarco G Baroni
Jul 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca ValentiValerio Nobili
Mar 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Silvia Sookoian, Carlos J Pirola
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Chih-Wen WangWan-Long Chuang
Feb 20, 2013·Journal of Hepatology·Martin BlachierFrançoise Roudot-Thoraval
Aug 21, 2013·Nature Reviews. Gastroenterology & Hepatology·Alexander WreeAriel E Feldstein
Oct 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eric TrépoPierre Deltenre
Nov 14, 2013·Seminars in Liver Disease·Marcin KrawczykFrank Lammert
Jun 12, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eriks SmagrisHelen H Hobbs

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Methods Mentioned

BETA
genotyping
biopsy

Software Mentioned

GraphPad Prism
GraphPad
SDS
SPSS

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