The Frizzled family: receptors for multiple signal transduction pathways

Genome Biology
Hui-Chuan Huang, P S Klein

Abstract

Frizzled genes encode integral membrane proteins that function in multiple signal transduction pathways. They have been identified in diverse animals, from sponges to humans. The family is defined by conserved structural features, including seven hydrophobic domains and a cysteine-rich ligand-binding domain. Frizzled proteins are receptors for secreted Wnt proteins, as well as other ligands, and also play a critical role in the regulation of cell polarity. Frizzled genes are essential for embryonic development, tissue and cell polarity, formation of neural synapses, and the regulation of proliferation, and many other processes in developing and adult organisms; mutations in human frizzled-4 have been linked to familial exudative vitreoretinopathy. It is not yet clear how Frizzleds couple to downstream effectors, and this is a focus of intense study.

References

Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·J C HsiehJ Nathans
Aug 14, 1999·Mechanisms of Development·D GradlD Wedlich
Jun 10, 2000·Science·M BoutrosM Mlodzik
Aug 25, 2001·Biochemical and Biophysical Research Communications·R YaoT Noda
Sep 21, 2001·Biochemical and Biophysical Research Communications·C C MalbonR T Moon
Apr 24, 2002·Developmental Cell·E David CohenElizabeth L Wilder
May 23, 2002·Developmental Cell·Paul N Adler
Jun 18, 2002·FEBS Letters·Heike Hering, Morgan Sheng
Aug 13, 2002·Nature Genetics·Johane RobitailleMark E Samuels
Sep 3, 2002·The Journal of Biological Chemistry·Chi-hwa Wu, Roel Nusse
Mar 15, 2003·Developmental Cell·Nicholas S TolwinskiEric Wieschaus
May 8, 2003·Journal of Cell Science·Clémence CarronMuriel Umbhauer
Sep 12, 2003·Developmental Cell·Michael T VeemanRandall T Moon

❮ Previous
Next ❯

Citations

Jan 11, 2005·The Journal of Pathology·Mohammad Ilyas
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mayumi F MillerEdward E Morrisey
Apr 13, 2012·Nucleic Acids Research·Paraskevi SalpeaBruce H Howard
Feb 4, 2009·Molecular and Cellular Biology·Heung-Sun KwonStanislav I Tomarev
Jun 17, 2006·Annual Review of Neuroscience·Mireille MontcouquiolMatthew W Kelley
Sep 22, 2007·BMC Bioinformatics·Qingliang Li, Luhua Lai
May 3, 2008·BMC Evolutionary Biology·N KameshNarayanan Manoj
Apr 27, 2013·BMC Genomics·Susan T HarbisonTrudy F C Mackay
Mar 16, 2007·PLoS Biology·Tsuyoshi Momose, Evelyn Houliston
May 19, 2006·Expert Opinion on Therapeutic Targets·Todd D Gould
Jul 25, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shovanlal GayenCongBao Kang
Dec 24, 2015·Frontiers in Cell and Developmental Biology·Nazanin F DolatshadGabor Földes
Aug 24, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Ritsuko TakadaShinji Takada
Nov 7, 2006·Neuropathology and Applied Neurobiology·Z ZhangH J Schluesener
Oct 20, 2006·Ophthalmic Genetics·Kimberly A DrenserMichael T Trese
Jun 1, 2006·European Journal of Cell Biology·Yogikala Prabhu, Ludwig Eichinger
Sep 3, 2016·Cancers·Alanna E Sedgwick, Crislyn D'Souza-Schorey
Feb 9, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Gregory GoleniaGregory M Kelly
Mar 9, 2017·Pharmacological Reports : PR·Yanhui LiuJun Li
Jun 25, 2005·Trends in Genetics : TIG·Jeffrey G WilliamsLudwig Eichinger
Aug 30, 2005·Current Opinion in Microbiology·Ludwig Eichinger, Angelika A Noegel
Mar 28, 2008·Gene Expression Patterns : GEP·Kristen SummerhurstPaula Murphy
Aug 31, 2014·Pharmacology & Therapeutics·Phuong N LeAntonio Jimeno
May 24, 2018·International Journal of Molecular Sciences·Chui-Mian ZengLi Fu
Nov 5, 2017·Biology Open·Muhammad Abu-ElmagdGrant N Wheeler
May 3, 2013·Nature·Chong WangRaymond C Stevens
Apr 1, 2006·Journal of Cellular Physiology·Yu-Feng DongHicham Drissi
Feb 20, 2014·Genesis : the Journal of Genetics and Development·Nicolas RobertJenifer C Croce
Jun 14, 2012·Protein Science : a Publication of the Protein Society·Jimin Pei, Nick V Grishin
Jun 3, 2006·Journal of Cellular Biochemistry·Stéphane TerryRalph Buttyan
Dec 12, 2018·The Journal of Biological Chemistry·Aaron H Nile, Rami N Hannoush
Aug 12, 2006·ChemMedChem·Edgar JacobyKlaus Seuwen
May 3, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Edmond Changkyun ParkJin-Kwan Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annual Review of Cell and Developmental Biology
A Wodarz, R Nusse
Proceedings of the National Academy of Sciences of the United States of America
A RattnerJ Nathans
Methods in Molecular Biology
Samantha Van Hoffelen, Michael A Herman
The Journal of Biological Chemistry
Wang A YanfengP S Klein
© 2022 Meta ULC. All rights reserved