The frog as a unique vertebrate model for studying the rhombomeric organization of functionally identified hindbrain neurons

Brain Research Bulletin
H StrakaE Gilland

Abstract

The segmental organization of cranial nerve efferent, vestibular, and precerebellar neurons of larval ranid frogs is essentially retained in adult frogs, indicating the absence of any substantial postembryonic longitudinal migration of hindbrain neurons in this group. Comparison of the rhombomeric organization of vestibulomotor and branchiomotor pathways across different species suggests that the frog hindbrain blueprint is common to most vertebrates. The unique segmental stability seen in frogs can be used to create a quantitative stereotactic map of the adult brain that mirrors the embryonic and larval rhombomeric framework. Such a map allows the large number of physiologically identified hindbrain neurons in adult frogs to be linked with their underlying genetic specification. Transgenic reporters and antisense knockdown of gene activities suspected of having necessary functions in patterning neurons within specific rhombomeres may allow direct testing of the proposed map.

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Citations

May 26, 2005·Respiratory Physiology & Neurobiology·Michael S Hedrick
Jun 6, 2003·Brain Research Bulletin·Adel Maklad, Bernd Fritzsch
Dec 2, 2005·The Journal of Comparative Neurology·Hans StrakaEdwin Gilland
Jan 3, 2013·Respiratory Physiology & Neurobiology·Michael J Klingler, Michael S Hedrick
Apr 24, 2010·Respiratory Physiology & Neurobiology·Nicholas M Mellen
Apr 27, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Carmen Díaz, Luis Puelles
Dec 20, 2018·ELife·Marcela Lipovsek, Richard Jt Wingate
Jan 31, 2019·Journal of Neurophysiology·Bernard CohenCatherine Cho
Jul 11, 2003·Journal of Neurophysiology·Hans StrakaEdwin Gilland
Nov 24, 2016·Frontiers in Neural Circuits·Francisco BranonerHans Straka
Feb 21, 2018·Frontiers in Neurology·Bernard CohenCatherine Cho

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