The frontal assessment battery is not useful to discriminate progressive supranuclear palsy from frontotemporal dementias

Parkinsonism & Related Disorders
M StamelouG U Höglinger

Abstract

The frontal assessment battery (FAB) has been suggested as a useful tool in the differential diagnosis of progressive supranuclear palsy (PSP) from Parkinson's disease (PD) and multiple system atrophy with parkinsonism (MSA-P). However, the utility of the FAB in the differential diagnosis of PSP from frontotemporal dementia (FTD) phenotypes is still under research. We performed the FAB, in a multi-centre cohort of 70 PSP, 103 FTD (N = 84 behavioral variant FTD, N = 10 semantic dementia, N = 9 progressive non-fluent aphasia), 26 PD and 11 MSA-P patients, diagnosed according to established criteria. Patients were also rated with the mini mental state examination and motor scales. The FAB total score showed a poor discriminatory power between PSP and FTD as a group [area under the curve (AUC) = 0.523]. Moreover, the FAB score showed no correlation with disease duration in PSP (r = 0.05) or FTD group (r = 0.04). In contrast, we confirmed that the FAB is clinically useful to differentiate PSP from PD and MSA-P (AUC = 0.927). In fact, the sum of two FAB subscores together (verbal fluency and Luria motor series) were as good as the total score in differentiating PSP from PD and MSA-P (AUC = 0.957). The FAB may not be a useful tool to ...Continue Reading

References

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Citations

Mar 8, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Maria StamelouUNKNOWN AL-108-231 Investigators, Tauros Investigators, and MDS-Endorsed PSP Study Group
Oct 11, 2016·PloS One·Alexander Frizell SantilloChrister Nilsson
Sep 8, 2017·Neuro-degenerative Diseases·Andrea PilottoBarbara Borroni
Jun 20, 2017·International Journal of Geriatric Psychiatry·Miriam Hurtado-PomaresEva María Navarrete-Muñoz
May 8, 2018·Alzheimer Disease and Associated Disorders·Valéria S BahiaMônica S Yassuda
Aug 13, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Lambros MessinisRónán O'Caoimh
Mar 1, 2017·Journal of Neural Transmission·Günter U HöglingerWolfgang H Jost
May 8, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Han Soo YooPhil Hyu Lee
Aug 20, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ciro Rosario IlardiAlessandro Iavarone

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