The FSH-HIF-1α-VEGF Pathway Is Critical for Ovulation and Oocyte Health but Not Necessary for Follicular Growth in Mice

Endocrinology
Chengyu LiHonglin Liu

Abstract

Follicle-stimulating hormone (FSH)-induced growth of ovarian follicles is independent of follicular vascularization. Recent evidence has indicated that follicular vascularization is critical to ovarian follicle development and survival. FSH, a gonadotropin that induces follicular growth and development, also acts as the major survival factor for antral follicles. FSH has been reported to stimulate angiogenesis in the theca layers mediated in part by the vascular endothelial growth factor A (VEGFA) and the transcription factor hypoxia inducible factor 1α (HIF-1α). However, it remains largely undetermined whether FSH-dependent growth and survival of antral follicles relies on FSH-induced vascularization. Here, we first demonstrated that induction of angiogenesis through the FSH-HIF-1α-VEGFA axis is not required for FSH-stimulated follicular growth in mouse ovary. FSH increased the total number of blood vessels in mouse ovarian follicles, which was correlated with elevated expression of VEGFA and HIF-1α in granulosa cells. In contrast, blocking of follicular angiogenesis using inhibitors against the HIF-1α-VEGFA pathway repressed vasculature formation in follicles despite FSH administration. Interestingly, by measuring follicular ...Continue Reading

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Citations

Sep 2, 2020·Reproduction in Domestic Animals = Zuchthygiene·Bajram BerishaMichael W Pfaffl
Mar 2, 2021·Journal of Agricultural and Food Chemistry·Rongmao HuaQingwang Li
Apr 8, 2021·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Yingfeng ShiNa Liu
Jun 18, 2021·Frontiers in Endocrinology·Yang GuoJian Fei
Aug 17, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yihui FengYing Zhao

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