The FTO gene is associated with adulthood obesity in the Mexican population.

Obesity
Marisela Villalobos-ComparánSamuel Canizales-Quinteros

Abstract

Common polymorphisms in the fat mass and obesity-associated gene (FTO) have shown strong association with obesity in several populations. In the present study, we explored the association of FTO gene polymorphisms with obesity and other biochemical parameters in the Mexican population. We also assessed FTO gene expression levels in adipose tissue of obese and nonobese individuals. The study comprised 788 unrelated Mexican-Mestizo individuals and 31 subcutaneous fat tissue biopsies from lean and obese women. FTO single-nucleotide polymorphisms (SNPs) rs9939609, rs1421085, and rs17817449 were associated with obesity, particularly with class III obesity, under both additive and dominant models (P = 0.0000004 and 0.000008, respectively). These associations remained significant after adjusting for admixture (P = 0.000003 and 0.00009, respectively). Moreover, risk alleles showed a nominal association with lower insulin levels and homeostasis model assessment of B-cell function (HOMA-B), and with higher homeostasis model assessment of insulin sensitivity (HOMA-S) only in nonobese individuals (P (dom) = 0.031, 0.023, and 0.049, respectively). FTO mRNA levels were significantly higher in subcutaneous fat tissue of class III obese indivi...Continue Reading

References

Nov 5, 1999·JAMA : the Journal of the American Medical Association·A MustW H Dietz
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Apr 17, 2004·American Journal of Human Genetics·C J HoggartP M McKeigue
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Feb 11, 2005·Nature Reviews. Genetics·Christopher G BellPhilippe Froguel
Nov 12, 2005·Human Genetics·Shweta ChoudhryUNKNOWN Genetics of Asthma in Latino Americans GALA Study
Jun 3, 2006·Obesity·Tuomo RankinenClaude Bouchard
May 15, 2007·Nature Genetics·Christian DinaPhilippe Froguel
Sep 25, 2007·Obesity·Catherine L SaundersDavid A Collier
Oct 12, 2007·Journal of Human Genetics·Jun OhashiRyutaro Ohtsuka
Dec 7, 2007·Molecular Genetics and Metabolism·Armand PeetersWim Van Hul

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Citations

Dec 23, 2011·Molecular Biology Reports·Haina WangJingyun Yang
Dec 14, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J R FernandezK Casazza
Nov 16, 2010·Nature Genetics·Chris ChurchRoger D Cox
Nov 20, 2013·Nature Reviews. Endocrinology·Ruth J F Loos, Giles S H Yeo
Apr 16, 2011·Genetic Testing and Molecular Biomarkers·Nuananong SealLyle G Best
Jul 10, 2010·American Journal of Epidemiology·Jiajun ShiXiao-Ou Shu
Feb 5, 2013·BMC Medical Genetics·Aurora Mejía-BenítezAmélie Bonnefond
Mar 19, 2013·BMC Medical Genetics·Carmela Farias da SilvaVanessa Suñé Mattevi
Jun 28, 2012·PloS One·Marisela Villalobos-ComparánSamuel Canizales-Quinteros
Dec 25, 2015·Journal of Diabetes and Its Complications·Sahar ElouejFlorin Grigorescu
Mar 16, 2013·Journal of Diabetes and Its Complications·Daniel Antonio de LuisManuel Gonzalez Sagrado
Jul 31, 2012·Journal of Health Economics·George L Wehby, Charles J Courtemanche
Jun 15, 2012·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Manish ParikhChristopher Still
Dec 18, 2013·Obesity Research & Clinical Practice·Lina WangBei Wang
Dec 14, 2011·European Journal of Internal Medicine·E TarabraF Rosina
Dec 7, 2010·Trends in Endocrinology and Metabolism : TEM·Rachel LarderAnthony P Coll
Sep 8, 2010·Biochemical and Biophysical Research Communications·Nicole J PoritsanosTooru M Mizuno
Jan 21, 2016·International Journal of Endocrinology·Myrte Merkestein, Dyan Sellayah
Aug 29, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J V van Vliet-OstaptchoukN C Onland-Moret
Aug 31, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J A JacobssonR Fredriksson
Oct 13, 2011·American Journal of Physical Anthropology·Soňa MačekováJana Carnogurská
Oct 28, 2011·Clinical and Translational Science·Kimberly R CoenenShari L Barkin
Feb 3, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Y Y YakoA P Kengne
Jul 18, 2009·The International Journal of Eating Disorders·Marsha D Marcus, Jennifer E Wildes
Dec 30, 2014·Gene·Wanida ChuentaRungsunn Tungtrongchitr
Apr 13, 2010·Trends in Genetics : TIG·Katherine A Fawcett, Inês Barroso
Aug 28, 2012·Diabetes·Marco Alberto Gamboa-MeléndezMaría Teresa Tusié-Luna

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