The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice

Food & Function
Jiayu YinShoudong Guo

Abstract

Hyperlipidemia is a major cause of atherosclerosis. Reverse cholesterol transport (RCT) is believed to attenuate hyperlipidemia and the progression of atherosclerosis. Although fucoidans are reported to have hypolipidemic effects, the underlying mechanisms are unclear. Furthermore, few reports have revealed the anti-atherosclerotic effects and the underlying mechanisms of fucoidans. This study was designed to investigate the anti-atherosclerotic effect and mechanisms of the fucoidan from seaweed A. nodosum. Our results demonstrated that the fucoidan administration ameliorated atherosclerotic lesion and lipid profiles in a dose-dependent manner in the apolipoprotein E-deficient (apoE-/-) mice fed a high-fat diet. In the apoE-/- mice liver, the fucoidan treatment significantly increased the expression of scavenger receptor B type 1 (SR-B1), peroxisome proliferator-activated receptor (PPAR) α and β, liver X receptor (LXR) α, ATP-binding cassette transporter (ABC) A1 and ABCG8; and markedly decreased the expression of PPARγ and sterol regulatory element-binding protein (SREBP) 1c, but not low-density lipoprotein receptor, proprotein convertase subtilisin/kexin type 9, cholesterol 7 alpha-hydroxylase A1, LXRβ and ABCG1. In the small...Continue Reading

References

Jul 1, 1982·Analytical Biochemistry·L J SilvestriJ M Settine
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·A VenkateswaranP Tontonoz
Oct 16, 2002·The Journal of Biological Chemistry·Hélène DuezBart Staels
Jan 1, 1961·Biochimica Et Biophysica Acta·A G LLOYDF A ROSE
Jan 1, 1961·Biochimica Et Biophysica Acta·A G LLOYD, K S DODGSON
Apr 30, 2005·Trends in Pharmacological Sciences·Joel P BergerPeter T Meinke
Jun 21, 2005·Journal of Cardiovascular Pharmacology·Vanessa DeclercqMohammed H Moghadasian
Mar 22, 2008·Journal of Cardiovascular Pharmacology·Mohammad Anwar HossainShinji Yokoyama
Apr 9, 2009·Bioscience, Biotechnology, and Biochemistry·Seiichirou NakayasuTatsuya Oda
Jul 22, 2010·Pharmaceutical Biology·Ling HuangYonghong Liu
Dec 4, 2010·Biochimica Et Biophysica Acta·Noemí RotllanJoan Carles Escolà-Gil
Mar 13, 2014·Journal of Medicinal Food·Diana M Hernández-CoronaManuel González-Ortiz
May 17, 2014·Nature Reviews. Drug Discovery·Cynthia Hong, Peter Tontonoz
Aug 22, 2014·Natural Product Research·Ho Duc CuongTran Thi Thanh Van
Sep 22, 2015·Marine Drugs·Janet Helen FittonSamuel S Karpiniec
Nov 26, 2015·Journal of Ethnopharmacology·M SaravananS Ignacimuthu
Apr 21, 2016·Journal of Pharmacological Sciences·Jinhee ParkDae-Hyun Hahm
Aug 12, 2016·Journal of Cellular and Molecular Medicine·Hua TianShoudong Guo
Nov 28, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Lu ZengBenJie Zhou
Mar 27, 2018·Annals of Medicine·Najmeh AhangariAlireza Pasdar
Apr 8, 2018·Life Sciences·Mariana Cerqueira LosaccoFrancemilson Goulart-Silva
Jun 16, 2018·Nature Reviews. Endocrinology·Bo Wang, Peter Tontonoz
Jun 16, 2018·International Journal of Biological Macromolecules·Yingjie XuYunliang Guo
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marina Valente BarrosoManuella Lanzetti
Dec 19, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shuzhen LiYue Zhang
Jan 18, 2019·Circulation Research·Natalie C WardRobert H Eckel
Jan 22, 2019·Natural Product Reports·Anthony R CarrollMichèle R Prinsep

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Citations

Jan 28, 2021·Foods·Rebeca AndréMaria Luísa Serralheiro
Mar 6, 2021·Molecular Therapy. Nucleic Acids·Xi YangYonghong Li
Apr 21, 2021·International Journal of Biological Macromolecules·Xiaoqian YangShoudong Guo
May 25, 2021·Frontiers in Molecular Biosciences·Ping LinShou-Dong Guo
Jun 16, 2021·Carbohydrate Polymers·Jiarui ZhaoShuliang Song

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Methods Mentioned

BETA
infrared spectrometry
PCR

Software Mentioned

Image
Clinx Image Analysis
Pro Plus

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