The Function and Prognostic Significance of Cripto-1 in Colorectal Cancer

Cancer Investigation
Jun SatoMichiaki Unno

Abstract

Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was positive in 68 out of 192 cases (35%) by immunohistochemistry. Cripto-1 expression was correlated with worse prognosis and was an independent prognostic factor. Cripto-1-silenced colorectal cancer cell lines had reduced cell proliferation, migration, and activation of Akt and MAPK signaling pathways in vitro, and decreased tumor growth and lymph node metastasis in vivo. Cripto-1 could be a useful prognostic biomarker and therapeutic target in colorectal cancer.

References

Aug 26, 1998·The Journal of Pathology·R L ByrneF C Hamdy
Mar 20, 1999·The Journal of Biological Chemistry·C BiancoD S Salomon
Mar 23, 2002·Molecular and Cellular Biology·Caterina BiancoDavid S Salomon
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jun 14, 2005·Current Topics in Developmental Biology·Caterina BiancoDavid S Salomon
Aug 27, 2005·Oncogene·Luigi StrizziDavid Salomon
Jul 21, 2006·Advances in Enzyme Regulation·James A McCubreyMassimo Libra
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Caterina BiancoNicola Normanno
Nov 28, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y P GongD J Gillett
Feb 27, 2007·The American Journal of Pathology·María Virtudes CéspedesRamon Mangues
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemRafael G Amado
Oct 18, 2007·Journal of Cellular Physiology·Mario MancinoCaterina Bianco
Nov 16, 2007·The New England Journal of Medicine·Derek J JonkerMalcolm J Moore
Mar 5, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rafael G AmadoDavid D Chang
Oct 24, 2008·The New England Journal of Medicine·Christos S KarapetisJohn R Zalcberg
Feb 4, 2010·International Journal of Oncology·Norikatsu MiyoshiMasaki Mori
Jul 10, 2010·The American Journal of Pathology·Caterina BiancoDavid S Salomon
Sep 9, 2010·International Journal of Cancer. Journal International Du Cancer·Cristina BosettiCarlo La Vecchia
Aug 25, 2011·British Journal of Cancer·A De LucaN Normanno
Dec 14, 2011·Growth Factors·Tadahiro NagaokaCaterina Bianco
Sep 18, 2013·Oncogenesis·D AhmedR A Lothe
Sep 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ren LiuParkash S Gill
Apr 22, 2014·Stem Cell Reports·Benjamin T SpikePeter C Gray
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jun 11, 2015·Oncotarget·Nadia P CastroDavid S Salomon
Sep 8, 2015·Cell Death and Differentiation·F FrancescangeliA Zeuner
Nov 26, 2015·The Clinical Respiratory Journal·Chun Hua XuQing Bo Wang
Jan 1, 2014·Journal of Kidney Cancer and VHL

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Citations

May 15, 2021·Biochemical and Biophysical Research Communications·Hodaka TayamaMichiaki Unno

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