The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection.

The FEBS Journal
Etienne Pays

Abstract

The discovery that apolipoprotein L1 (APOL1) is the trypanolytic factor of human serum raised interest about the function of APOLs, especially following the unexpected finding that in addition to their protective action against sleeping sickness, APOL1 C-terminal variants also cause kidney disease. Based on the analysis of the structure and trypanolytic activity of APOL1, it was proposed that APOLs could function as ion channels of intracellular membranes and be involved in mechanisms triggering programmed cell death. In this review, the recent finding that APOL1 and APOL3 inversely control the synthesis of phosphatidylinositol-4-phosphate (PI(4)P) by the Golgi PI(4)-kinase IIIB (PI4KB) is commented. APOL3 promotes Ca2+ -dependent activation of PI4KB, but due to their increased interaction with APOL3, APOL1 C-terminal variants can inactivate APOL3, leading to reduction of Golgi PI(4)P synthesis. The impact of APOLs on several pathological processes that depend on Golgi PI(4)P levels is discussed. I propose that through their effect on PI4KB activity, APOLs control not only actomyosin activities related to vesicular trafficking, but also the generation and elongation of autophagosomes induced by inflammation.

References

May 8, 2002·The Journal of Biological Chemistry·Weinong GuoJeanne M Nerbonne
Nov 14, 2002·Molecular Neurobiology·J Gregor Sutcliffe, Elizabeth A Thomas
Dec 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Phil Ok KohMichael S Lidow
Dec 25, 2002·The Journal of Cell Biology·Mariusz KarbowskiRichard J Youle
Mar 7, 2003·Nature·Luc VanhammeEtienne Pays
Jul 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jesper GromadaPer-Olof Berggren
May 13, 2006·The Journal of Clinical Investigation·Christina SchleckerBarbara E Ehrlich
Jul 19, 2006·Cellular and Molecular Life Sciences : CMLS·B Vanhollebeke, E Pays
Dec 29, 2006·The New England Journal of Medicine·Benoit VanhollebekeEtienne Pays
Aug 28, 2007·The Journal of Biological Chemistry·Thomas StrahlJames B Ames
Feb 9, 2008·Cell Death and Differentiation·S Lucken-ArdjomandeJ-C Martinou
May 29, 2008·The Journal of Biological Chemistry·Guanghua WanChien-an A Hu
Jul 18, 2008·Schizophrenia Research·Sakae TakahashiMing T Tsuang
Sep 17, 2008·Nature Genetics·W H Linda KaoUNKNOWN Family Investigation of Nephropathy and Diabetes Research Group
Sep 17, 2008·Nature Genetics·Jeffrey B KoppCheryl A Winkler
Sep 20, 2008·Human Molecular Genetics·Amélie PitonGuy A Rouleau
Dec 19, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·K C L TorresM A Romano-Silva
May 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marina MikhaylovaMichael R Kreutz
Dec 22, 2009·Nature Genetics·Elizabeth J BrownMartin R Pollak
Aug 24, 2010·Current Opinion in Cell Biology·Stephane G Rolland, Barbara Conradt
Nov 16, 2010·Cell Host & Microbe·Nicholas S Heaton, Glenn Randall
Nov 26, 2010·Cellular and Molecular Neurobiology·Jamie L WeissRobert D Burgoyne

❮ Previous
Next ❯

Citations

Mar 16, 2021·Current Opinion in Immunology·Etienne Pays, Derek P Nolan

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
biopsies
GTPases

Software Mentioned

APOL3

Related Concepts

Related Feeds

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

© 2022 Meta ULC. All rights reserved