The function of chromatin modifiers in lineage commitment and cell fate specification

The FEBS Journal
Jason Signolet, Brian Hendrich

Abstract

Proteins that modify the structure of chromatin are known to be important for various aspects of metazoan biology including development, disease and possibly ageing. Yet functional details of why these proteins are important, i.e. how their action influences a given biological process, are lacking. While it is now possible to describe the biochemistry of how these proteins remodel chromatin, their chromatin binding profiles in cell lines, or gene expression changes upon loss of a given protein, in very few cases has this easily translated into an understanding of how the function of that protein actually influences a developmental process. Given that many chromatin modifying proteins will largely exert their influence through control of gene expression, it is useful to consider developmental processes as changes in the gene regulatory network (GRN), with each cell type exhibiting a unique gene expression profile. In this essay we consider the impact of two abundant and highly conserved chromatin modifying complexes, namely the nucleosome remodelling and deacetylation (NuRD) complex and the polycomb repressive complex 2 (PRC2), on the change in GRNs associated with lineage commitment during early mammalian development. We propos...Continue Reading

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Dec 15, 2015·Ageing Research Reviews·Sukhleen Kour, Pramod C Rath
Apr 2, 2015·The FEBS Journal·Pura Muñoz-Cánoves, Luciano Di Croce
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Jul 26, 2021·Current Opinion in Structural Biology·Luke T BaileyThomas Schalch

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Methods Mentioned

BETA
acetylation

Software Mentioned

NuRD

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