The function of E- and Id proteins in lymphocyte development

Nature Reviews. Immunology
Isaac Engel, Cornelis Murre

Abstract

Helix-loop-helix proteins are essential factors for lymphocyte development and function. In particular, E-proteins are crucial for commitment of lymphoid progenitors to the B- and T-cell lineages. E-proteins are negatively regulated by the Id class of helix-loop-helix proteins. The Id proteins function as dominant-negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here, we review the role of E-proteins and their Id protein antagonists in lymphocyte proliferation and developmental progression. In addition, we discuss how E-protein activity and Id gene expression are regulated by T-cell receptor (TCR) and pre-TCR-mediated signalling.

References

Feb 11, 1990·Nucleic Acids Research·P HenthornT Kadesch
Aug 1, 1995·Molecular and Cellular Biology·C P Shen, T Kadesch
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·D T DudleyA R Saltiel
Jul 1, 1995·The Journal of Experimental Medicine·H T PetrieS Mazel
Nov 1, 1993·Immunology Today·D I Godfrey, A Zlotnik
Nov 18, 1994·Science·C Saint-RufH von Boehmer
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C N LeveltK Eichmann
Apr 1, 1996·Current Opinion in Immunology·J C Zúñiga-Pflücker, M J Lenardo
Dec 1, 1996·Molecular and Cellular Biology·S R SloanT Kadesch
Apr 7, 1998·Molecular and Cellular Biology·P OrdentlichT Kadesch
Jun 20, 1998·Molecular and Cellular Biology·Y ZhuangM Dai
Oct 6, 1998·Annual Review of Biochemistry·J Massagué
Jan 20, 1999·The Journal of Experimental Medicine·G BainC Murre
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·I Engel, C Murre
May 14, 1999·Current Opinion in Immunology·R J Benschop, J C Cambier
Aug 24, 1999·Molecular and Cellular Biology·L PanY Zhuang
Nov 24, 1999·Molecular and Cellular Biology·D KimX H Sun
Dec 10, 1999·The Journal of Experimental Medicine·G BainC Murre
Dec 28, 1999·Molecular and Cellular Biology·M E Massari, C Murre

❮ Previous
Next ❯

Citations

Jan 17, 2004·Experimental Hematology·Eric Lécuyer, Trang Hoang
Dec 31, 2003·Gene·Kikumi Hata, Junichiro Mizuguchi
Apr 12, 2003·Experimental Cell Research·Jean-Philippe CoppéPierre-Yves Desprez
Oct 29, 2003·Tissue & Cell·Xiaozhou JiangJunichiro Mizuguchi
Sep 11, 2002·Seminars in Immunology·Alison M Michie, Juan Carlos Zúñiga-Pflücker
Apr 12, 2003·Seminars in Immunology·Warren S Pear, Freddy Radtke
Nov 30, 2002·Seminars in Immunology·Susan S ProhaskaMotonari Kondo
Nov 30, 2002·Seminars in Immunology·Ellen V Rothenberg
Nov 30, 2002·Seminars in Immunology·Rebecca H Lian, Vinay Kumar
Mar 26, 2003·Seminars in Cell & Developmental Biology·Yiping He, Warren S Pear
Dec 24, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Gautam DravidGay M Crooks
Jul 7, 2005·Nature Reviews. Immunology·Harald von Boehmer
Mar 14, 2007·Immunology and Cell Biology·Mark S Sundrud, Anjana Rao
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christopher B FrancoEllen V Rothenberg
Nov 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Laurel A MonticelliAnanda W Goldrath
Feb 9, 2010·The Journal of Biological Chemistry·Shuyang YuHai-Hui Xue
Apr 14, 2004·The Journal of Experimental Medicine·Melanie W QuongCornelis Murre
Jun 7, 2006·The Journal of Experimental Medicine·Annette I GarbeHarald von Boehmer
Feb 17, 2006·Biology of Reproduction·Amy D GulticeThomas L Brown
Feb 4, 2011·Genes & Development·Joseph W LandryCarl Wu
Mar 23, 2005·Acta Pharmacologica Sinica·Xiao-jun LiJunichiro Mizuguchi
May 18, 2006·Molecular and Cellular Biology·Gerson RothschildAnna Lasorella
Aug 18, 2004·Molecular and Cellular Biology·Zengbiao Qi, Xiao-Hong Sun
Oct 10, 2007·Biochemistry. Biokhimii︠a︡·E K KoltsovaT P Vavilova
Nov 5, 2002·Annual Review of Immunology·Timothy K StarrKristin A Hogquist
Mar 18, 2005·Annual Review of Immunology·Ellen V Rothenberg, Tom Taghon
Mar 23, 2006·Annual Review of Immunology·Bianca Blom, Hergen Spits
Mar 23, 2006·Annual Review of Immunology·James P Di Santo
Mar 23, 2006·Annual Review of Immunology·Catherine V LaiosaThomas Graf
Oct 9, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael J LipinskiColeen A McNamara
Sep 18, 2008·Circulation Research·Kamal Rahmouni, Curt D Sigmund
Jan 13, 2012·PloS One·Theresa J BarberiAnthony R Means
Mar 1, 2012·Genetics and Molecular Research : GMR·C Ronpirin, T Tencomnao
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lisa K McNeilKristin A Hogquist

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.