The function of fimbriae in Myxococcus xanthus. II. The role of fimbriae in cell-cell interactions

Canadian Journal of Microbiology
W J DobsonT H MacRae

Abstract

Anti-fimbriae antiserum specifically inhibited swarming but no gliding motility per se in Myxococcus xanthus. However, formation of motile aggregates on agar and clumps in liquid media correlated with the presence of fimbriae. Ethylenediaminetetraacetic acid which inhibited swarming also inhibited fimbriae formation. Direct electron-microscopic observations revealed that fimbriae establish contact with apposing cell surfaces. Intact but not depolymerized fimbriae exhibited hemagglutination activity against guinea pig erythrocytes. This activity was inhibited by mannose, N-acetyl-D-galactosamine, and to a lesser degree by fructose, raffinose, melibiose, and alpha-methyl-D-mannoside. It is concluded that fimbriae are organelles which function to establish and maintain intercellular contacts, perhaps by a lectin-like function, during the coordinated movement of cell aggregates' (swarming) in myxobacteria. This hypothesis is supported by the observations of other workers that genes determining movement of cells in groups also control fimbriation in M. xanthus.

References

Oct 24, 2006·Journal of Bacteriology·Marielena ChaviraWenyuan Shi
Jan 7, 2014·Journal of Bacteriology·Xueming WeiD Wall
Jan 1, 1983·Critical Reviews in Microbiology·G W Jones, R E Isaacson
Jan 1, 1987·Critical Reviews in Microbiology·L J Shimkets
Jul 9, 2002·Microbiology·Rhonda I HobbMichael P Jennings
Apr 27, 1999·Molecular Microbiology·D Wall, D Kaiser

Related Concepts

Melibiose
Fructose
Cell Motility
Agar
Cavia
Hemagglutination
Immune Sera
Motility
Myxococcus xanthus
Acetylgalactosamine

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