The function of long non-coding RNA MT1JP in the development and progression of gastric cancer

Pathology, Research and Practice
Zhongchuan LvYinlin Ge

Abstract

Gastric cancer is one of the most common malignant tumors with the third mortality rate of cancer in world. A larger number of researches showed that genetic factors played an important role in the development of gastric cancer. More and more evidences have indicated that lncRNAs can regulate the gene expression through the transcription, post transcription and epigenetic levels including cancer invasion and metastasis, cell differentiation and apoptosis. However, the mechanisms of lncRNAs in the pathogenesis of gastric cancer remaining unclear. LncRNA MT1JP overexpression vector was constructed and then transfected into gastric cancer cells. Further CCK-8 and transwell detection showed that lncRNA MT1JP exerted an evident inhibition role on proliferation, migration and invasion. By combining molecular cell biology experiments of the reporter gene, cell overexpression or interference and Western blot, we found that lncRNA MT1JP may regulate FBXW7 expression involved in the occurrence and development of gastric cancer. The results of this study not only explain the role of lncRNA MT1JP in the development of gastric cancer, but also provide important ideas and clues for the study of genetic regulation mechanism in gastric cancer.

Citations

Jun 30, 2019·International Journal of Molecular Sciences·Xuda MaYongmei Li
Sep 24, 2019·Cancer Letters·Min LinZhi-Wei Wang
Jan 4, 2020·Experimental and Molecular Pathology·Soudeh Ghafouri-Fard, Mohammad Taheri
Mar 27, 2021·Technology in Cancer Research & Treatment·Bibo TanYong Li

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