The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism

Journal of Cancer Research and Clinical Oncology
Yanhua SunGuiying Wang

Abstract

Increasing evidence has revealed that mechanical stress and elevated mechanical signals promote malignant tumor transformation and metastasis. This study aimed to explore the function of the mechanically activated ion-channel Piezo1 in the colon cancer metastasis and its potential regulatory mechanism. First, we examined the expression levels of Piezo1 and mitochondrial calcium uniporter (MCU) both in colon cancer tissues and assessed the prognostic value of Piezo1 and MCU in a colon cancer cohort (n = 110). Second, functional assays were performed to investigate the effects of Piezo1 and MCU on colon cancer cell migration, invasion, and mitochondrial membrane potential. Third, we analyzed the expression of Piezo1, MCU, and HIF-1α by overexpressing/silencing each other's expression. We found that Piezo1 was up-regulated and MCU was down-regulated in colon cancer tissues. Piezo1 and MCU were both correlated with poor prognosis of patients with colon cancer. Overexpressing Piezo1 and silencing MCU could promote colon cancer cell migration and metastasis, reduce mitochondrial membrane potential, and promote each other's expression. We also found that HIF-1α was up-regulated in colon cancer tissues. Additionally, silencing Piezo1 i...Continue Reading

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Citations

Jan 14, 2021·Journal of Cellular and Molecular Medicine·Xiaofei WangXudong Song
Feb 13, 2021·BioMed Research International·Daxue ZhuXuewen Kang
Mar 24, 2021·Trends in Pharmacological Sciences·Ali MominXi Huang
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