The function of targeted host genes determines the oncogenicity of HBV integration in hepatocellular carcinoma

Journal of Hepatology
Xiaojun LiFengmin Lu

Abstract

Although hepatitis B virus (HBV) integration into the human genome has been considered as one of the major causative factors to hepatocarcinogenesis, the underlying mechanism(s) was still elusive. Here we investigate the essential difference(s) of HBV integration between HCC tumor and adjacent non-tumor tissues and explore the factor(s) that determine the oncogenicity of HBV integration. 1115 HBV integration sites were collected from four recent studies. Functional annotation analysis of integration targeted host genes (ITGs) was performed using DAVID based on Gene Ontology and KEGG pathway databases. Array-based expression profiles, real-time qPCR and western blot were used to detect the expression of recurrent integration targeted genes (RTGs). The biological consequences of the overexpression of UBXN8 in 8 HCC cell lines were studied in vitro. HBV is prone to integrate in genic regions (exons, introns, and promoters) and gene-dense regions. Functional annotation analysis reveals that, compared to those in adjacent non-tumor tissues, ITGs in HCC tumor tissues were significantly enriched in functional terms related to negative regulation of cell death, transcription regulation, development and differentiation, and cancer relat...Continue Reading

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Citations

Sep 28, 2014·Best Practice & Research. Clinical Gastroenterology·Jean-Charles Nault
Sep 30, 2015·International Journal of Cancer. Journal International Du Cancer·Ruiyang ZhangFengmin Lu
Jul 15, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V SchinzariS Piconese
Dec 13, 2016·International Journal of Cancer. Journal International Du Cancer·Xiaobo YangHaitao Zhao
Apr 11, 2017·Viruses·Thomas TuStephan Urban
Dec 22, 2017·Journal of Gastroenterology and Hepatology·Bobin HuJianning Jiang
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Aug 9, 2018·Emerging Microbes & Infections·Magdalena Agnieszka BudzinskaThomas Tu
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May 1, 2020·International Journal of Cancer. Journal International Du Cancer·Mengge LiHong Tu
Mar 14, 2020·Cancers·Maria Grazia RefoloRosalba D'Alessandro
Aug 3, 2020·Journal of Viral Hepatitis·Wanjia ZengFengmin Lu
Sep 4, 2015·World Journal of Gastroenterology : WJG·Jie WangFeng-Min Lu
Feb 7, 2020·Nature Genetics·Marc ZapatkaUNKNOWN PCAWG Consortium
Jun 3, 2015·World Journal of Gastroenterology : WJG·Shan-Long DingFeng-Min Lu
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Dec 15, 2020·Technology in Cancer Research & Treatment·Rongming WangJianning Jiang
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May 29, 2021·Journal of Hepatocellular Carcinoma·Yu JiangJian Zhang
Jun 3, 2021·Cancers·Yuichiro HatanoAkira Hara
Jul 6, 2021·Journal of Clinical and Translational Hepatology·Dake ZhangChangqing Zeng
Aug 11, 2021·Viruses·Bingqian Qu, Richard J P Brown
Sep 7, 2021·Frontiers in Molecular Biosciences·Chia-Chen ChenXiangmei Chen

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