PMID: 5971009Sep 1, 1966Paper

The function of the golgi complex in transitional epithelium. Synthesis of the thick cell membrane

The Journal of Cell Biology
R M Hicks


The superficial squamous cells of rat transitional epithelium are limited, on their luminal face, by an asymmetrically thickened membrane. Patches of similar thick membrane are found in the walls of the Golgi cisternae and it is suggested that the Golgi system is the site of assembly of the thick plasma membrane. This implies membrane flow from the Golgi apparatus to the cell surface, and there is indirect evidence that the membrane is transported in the form of fusiform vacuoles, derived from the Golgi cisternae, which fuse with, and become part of, the free cell membrane. Uptake of injected Imferon shows that similar, large, thick-walled vacuoles may be formed by invagination of the free cell surface. Some of these vacuoles are subsequently transformed into multivesicular bodies and autophagic vacuoles. The formation of other large heterogeneous bodies is described, and some of these are shown to have acid phosphatase activity.


Jul 1, 1965·The Journal of Cell Biology·R M Hicks
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT
Apr 1, 1963·The Journal of Cell Biology·H H MOLLENHAUER, W G WHALEY
Feb 1, 1964·The Journal of Cell Biology·T F ROTH, K R PORTER
Sep 17, 1964·Zeitschrift für Zellforschung und mikroskopische Anatomie·E W DANIELS
Feb 1, 1965·The Journal of Cell Biology·N M KANCZAKW B ELLIOTT
Jul 1, 1965·The American Journal of Anatomy·D S FRIEND, M J MURRAY

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