PMID: 25775863Mar 18, 2015Paper

The functional activity of thyroid of male rats with acute and mild streptozotocin diabetes

Zhurnal evoliutsionnoĭ biokhimii i fiziologii
I V MoyseyukA O Shpakov

Abstract

The type 1 diabetes mellitus (DM1) and dysfunction of thyroid are the most common endocrine diseases, which are interrelated. However, the molecular mechanisms of thyroid dysfunction in DM1 and the role of adenylyl cyclase signaling system (ACSS) in this process remain poorly understood. Typically for studying etiology and pathogenesis of thyroid diseases in DM1 the models of acute DM1 induced by high doses of streptozotocin (STZ) are used. At the same time, a suitable model for this purpose is the model of mild DM1 induced by moderate doses of STZ, which more closely resembles human DM1. The aim of this work was a comparative study of the thyroid functional state in rats with 30-day acute DM1 induced by injection of STZ at a dose of 65 mg/kg, and in rats with the 30- and 210-day mild DM1 induced by three consecutive injections of STZ at medium doses (30-40 mg/kg). For this purpose in diabetic animals the levels of thyroid hormones and TSH and the functional activity of hormone-sensitive ACSS in membranes isolated from thyroid were studied. It was shown that in blood of rats with acute DM1 the levels of fT4, fT3 and tT3 were decreased by 45%, 23% and 19%, respectively, while the level of TSH did not changed significantly. In ra...Continue Reading

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