The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis

International Journal of Molecular Sciences
Jiaming SuJingji Jin

Abstract

Changes in chromatin structure and heritably regulating the gene expression by epigenetic mechanisms, such as histone post-translational modification, are involved in most cellular biological processes. Thus, abnormal regulation of epigenetics is implicated in the occurrence of various diseases, including cancer. Human MOF (males absent on the first) is a member of the MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of histone acetyltransferases (HATs). As a catalytic subunit, MOF can form at least two distinct multiprotein complexes (MSL and NSL) in human cells. Both complexes can acetylate histone H4 at lysine 16 (H4K16); however, the NSL complex possesses broader substrate specificity and can also acetylate histone H4 at lysines 5 and 8 (H4K5 and H4K8), suggesting the complexity of the intracellular functions of MOF. Silencing of MOF in cells leads to genomic instability, inactivation of gene transcription, defective DNA damage repair and early embryonic lethality. Unbalanced MOF expression and its corresponding acetylation of H4K16 have been found in certain primary cancer tissues, including breast cancer, medulloblastoma, ovarian cancer, renal cell carcinoma, colorectal carcinoma, gastric cancer, as well as non-small cell lung canc...Continue Reading

References

Aug 15, 2000·Annual Review of Biophysics and Biomolecular Structure·F DydaA B Hickman
Oct 29, 2000·Cell·R L Kelley, M I Kuroda
Mar 8, 2002·EMBO Reports·Davide F V CoronaJohn W Tamkun
Sep 28, 2002·Nature·Alexander W BirdMichael F Christman
Mar 4, 2003·EMBO Reports·Andrew A Travers
May 29, 2003·Molecular Cell·Alessia BuscainoAsifa Akhtar
Jun 13, 2003·Trends in Genetics : TIG·Michael J CarrozzaJacques Côté
Mar 10, 2004·Biochemistry·Evdokia PashevaIliya G Pashev
May 25, 2004·Oncogene·Narayanan Gopalakrishna IyerCarlos Caldas
Jan 7, 2005·The EMBO Journal·Jing WangStanley J Korsmeyer
Jun 1, 2005·Molecular and Cellular Biology·Arun GuptaTej K Pandita
Jul 19, 2005·Molecular and Cellular Biology·Mikko TaipaleAsifa Akhtar
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yingli SunBrendan D Price
Oct 19, 2005·The Journal of Biological Chemistry·Jingji JinJoan Weliky Conaway
Nov 1, 2005·Trends in Biochemical Sciences·Jingji JinThomas Kusch
Feb 14, 2006·Science·Michael Shogren-KnaakCraig L Peterson
Aug 15, 2006·Trends in Cell Biology·Massimo SquatritoBruno Amati
Oct 19, 2006·Journal of the National Cancer Institute·George S Mack
Dec 26, 2006·Molecular Cell·Stephen M SykesSteven B McMahon
Feb 27, 2007·Cell·Bradley E BernsteinEric S Lander
Feb 27, 2007·Cell·Tony Kouzarides
Mar 24, 2007·Nature Reviews. Molecular Cell Biology·Kenneth K Lee, Jerry L Workman
Apr 19, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Wenchu LinSharon Y R Dent
May 15, 2007·The Journal of Biological Chemistry·Young-Wook ChoKai Ge
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elise A OlsenMadeleine Duvic
Aug 19, 2007·Oncogene·S ReaA Akhtar
Oct 2, 2007·Seminars in Cell & Developmental Biology·Ken van Holde, Jordanka Zlatanova
Jan 15, 2008·The International Journal of Biochemistry & Cell Biology·Dessislava TopalovaEvdokia A Pasheva
Mar 11, 2008·Nature Structural & Molecular Biology·Tamaki SuganumaJerry L Workman
Apr 24, 2008·Molecular Medicine·John R KluneAllan Tsung
May 31, 2008·Current Opinion in Cell Biology·Lorraine Pillus

❮ Previous
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Citations

Feb 2, 2018·Journal of Clinical Medicine·Alissa duPuy Guarnaccia, William Patrick Tansey
Aug 26, 2017·Cell Death and Differentiation·Simon M CarrNicholas B La Thangue
Apr 15, 2017·Biochemical Society Transactions·Maïté LeturcqAnne-Sophie Vercoutter-Edouart
Jun 1, 2018·Annual Review of Genomics and Human Genetics·Liad Holtzman, Charles A Gersbach
Oct 5, 2018·Annual Review of Entomology·Karl M GlastadMichael A D Goodisman
May 6, 2019·Pathology Oncology Research : POR·Jingchun QinHuixuan Li
Oct 3, 2019·Nature Cell Biology·Varvara V Popova, Jerry L Workman
Jul 22, 2020·Molecular Plant-microbe Interactions : MPMI·Guangyuan WangWenxing Liang
Jun 15, 2016·American Journal of Hematology·José AdélaideVéronique Gelsi-Boyer
Nov 11, 2016·PLoS Pathogens·Karl KuchlerNeeraj Chauhan
Nov 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yvonne LoratClaudia E Rübe
Dec 3, 2020·Frontiers in Oncology·Donglu WuDa Liu
Oct 13, 2020·Biomolecules & Therapeutics·Huihui ZhuJingji Jin
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiawen CaoDanyan Cao
Feb 23, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Jasmine A Burrell, Jacqueline M Stephens
Sep 3, 2020·Seminars in Cancer Biology·Sabah AkhtarHesham M Korashy
Jun 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yi WangBo Liu

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Methods Mentioned

BETA
ubiquitination
histone acetylation
acetylation
acetylate
immunoprecipitation
nuclear translocation
ChIP

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