The functional asymmetry of ON and OFF channels in the perception of contrast

Journal of Neurophysiology
Yaoguang JiangV A Casagrande

Abstract

To fully understand the relationship between perception and single neural responses, one should take into consideration the early stages of sensory processing. Few studies, however, have directly examined the neural underpinning of visual perception in the lateral geniculate nucleus (LGN), only one synapse away from the retina. In this study we recorded from LGN parvocellular (P) ON-center and OFF-center neurons while monkeys either passively viewed or actively detected a full range of contrasts. We found that OFF neurons were more sensitive in detecting negative contrasts than ON neurons were in detecting positive contrasts. Also, OFF neurons had higher spontaneous activities, higher peak response amplitudes, and were more sustained than ON neurons in their contrast responses. Puzzlingly, OFF neurons failed to show any significant correlations with the monkeys' perceptual choices, despite their greater contrast sensitivities. If, however, choice probabilities were calculated from interspike intervals instead of spike counts (thus taking into account the higher firing rates of OFF neurons), OFF neurons but not ON neurons were significantly correlated with behavioral choices. Taken together, these results demonstrate in awake, b...Continue Reading

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Citations

Feb 20, 2019·Journal of Vision·Lukas F Schaeffner, Andrew E Welchman
Oct 11, 2017·Integrative and Comparative Biology·Finlay J StewartKentaro Arikawa
Jun 28, 2019·Biological cybernetics·Agnieszka PregowskaJanusz Szczepanski
Sep 22, 2020·Translational Vision Science & Technology·Anthony M NorciaJeffrey L Goldberg

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