The functional consequences of colectomy

American Journal of Surgery
H K Wright

Abstract

The colon plays a decisive role in salt and water conservation in the intact human, normally removing from the terminal intestine approximately one liter of isotonic fluid that escapes small bowel absorption. The primary purpose of this colon function is probably to prevent extracellular fluid volume depletion and only incidentally to produce a normal solid stool. The patient with an ileostomy can partly adapt to replace the absorptive capacity lost after colectomy but is still vulnerable if salt and water intake ceases completely. In contrast, patients with ileorectostomies and some patients with continent ileostomies can almost totally adapt to loss of the colon. These findings suggest that the ileal mucosa can adapt under certain conditions to absorb at rates and concentrations previously thought impossible. This property of ileal mucosa might be utilized in the future to significantly improve the condition of patients who require total colectomy.

References

Apr 1, 1972·American Journal of Surgery·H K Wright, M D Tilson
Jan 1, 1970·Digestion·R N GranthamE D Jacobson
Feb 1, 1969·American Journal of Surgery·H K WrightT Herskovic
May 1, 1969·The Journal of Surgical Research·H K WrightT Herskovic
Nov 1, 1966·The Journal of Clinical Investigation·P Kramer
Sep 17, 1955·Journal of the American Medical Association·R C LILLEHEI, O H WANGENSTEEN
Sep 1, 1962·The Journal of Clinical Investigation·R LEVITANF J INGELFINGER

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Citations

Aug 1, 1977·The American Journal of Digestive Diseases·G N TytgatA van den Ende
May 13, 2008·Diseases of the Colon and Rectum·Y Nancy YouJeffrey Harrington
Nov 4, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J MagdeburgA Rickert
Nov 1, 1981·Histopathology·P BechiC Cortesini
Jun 1, 1996·Scandinavian Journal of Gastroenterology·H Hove, P B Mortensen
May 10, 2003·Scandinavian Journal of Gastroenterology·K W EckerU Achenbach
Apr 7, 2007·The American Journal of Clinical Nutrition·Kelly R WalshMark L Failla
Jul 6, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Emanuele D L UrsoQuoc Riccardo Bao

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