The functional genomic studies of resveratrol in respect to its anti-cancer effects

Biotechnology Advances
Lukasz Huminiecki, Jarosław Horbańczuk

Abstract

Resveratrol has anti-cancer effects in vitro, and hypothetical chemopreventive effects in vivo. Effects are pleiotropic, mediated by changes in expression of many genes and epigenetic reprogramming. Thus, they are well suited for functional genomic studies. We carried out systematic review of such studies (reflecting also on technological progress). Differentially expressed genes commonly linked to resveratrol treatment were linked to cell cycle, proliferation, and apoptosis. However, it is unclear if these are primary and specific targets of resveratrol. We conclude by discussing areas where additional functional genomic studies are desirable, including experiments that better model in vivo effects of dietary intake.

Citations

Jun 4, 2019·Plant Cell Reports·Raju NainiVudem Dashavantha Reddy
Sep 9, 2020·Journal of Cancer Research and Clinical Oncology·Yinan YangZhi Qi
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena D PieczynskaJaroslaw O Horbanczuk
Jul 26, 2019·International Journal of Molecular Sciences·Yu JiangZezheng Pan
Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jian LinDongfeng Chen
Jun 26, 2020·World Journal of Microbiology & Biotechnology·Atieh Hashemi
Jul 9, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yu LiuJian-Da Zhou
Aug 19, 2021·Proceedings of the National Academy of Sciences of the United States of America·Linfeng YangHaifeng Ye

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