The functional roles of 11 beta-HSD1: vascular tissue, testis and brain

Molecular and Cellular Endocrinology
D J MorrisMatthew P Hardy

Abstract

Glucocorticoid hormones bind both glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) exerting a broad spectrum of actions in various tissues. The concentrations of glucocorticoid hormones in the target cells are regulated by 11 beta-hydroxysteroid dehydrogenases, type 1 (11 beta-HSD1) and type 2 (11 beta-HSD2). 11 beta-HSD2 is a unidirectional dehydrogenase, which inactivates biologically active glucocorticoid into inert metabolite, while 11 beta-HSD1 is a bi-directional oxidoreductase, which either inactivates biologically active glucocorticoid or activates inert metabolite into active forms. GRs and MRs are present in various tissues and mediate a broad spectrum of physiological actions. The co-existence of 11 beta-HSD1 with these two types of receptors plays an important role in regulation of glucocorticoid actions. This review examines the roles of 11 beta-HSD1 in vascular tissues, testis, brain and other tissues such as placental, retinal and adipose tissues.

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Citations

Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·D DelucaJ Adamski
May 8, 2004·Molecular and Cellular Endocrinology·R MindnichJ Adamski
Jun 26, 2013·Journal of Natural Products·Mei-Ling HanJian-Min Yue
Jan 23, 2014·Molecular and Cellular Endocrinology·Carlos F LagosCarlos E Fardella
May 28, 2004·Metabolism: Clinical and Experimental·David J MorrisAndrew S Brem
Oct 11, 2005·Trends in Endocrinology and Metabolism : TEM·Christiné S RigsbyAnne M Dorrance
Sep 29, 2005·Molecular and Cellular Endocrinology·Ren-Shan GeMatthew P Hardy
Sep 29, 2005·Molecular and Cellular Endocrinology·Syed A LatifDavid J Morris
Mar 19, 2009·Orthopedics·Robert Z TashjianRichard M Terek
Jun 19, 2017·Steroids·David J Morris, Jason M Ridlon
Feb 26, 2009·British Journal of Pharmacology·Patrick W F HadokeBrian R Walker
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Bart T PhillipsKyle E Orwig
Jan 30, 2020·Applied Microbiology and Biotechnology·Amit PratushZhong Hu
Apr 3, 2021·Frontiers in Endocrinology·Dijana Z MarinkovicTatjana S Kostic

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