PMID: 26796305Jan 23, 2016Paper

The Functions of Histone Modification Enzymes in Cancer

Current Protein & Peptide Science
Ruilin WangMeixia Zhang

Abstract

Posttranslational modifications of proteins critically regulate the function, localization, and stability of target proteins. Histone modification is one of the regulatory mechanisms that modulate the chromatin structure and thereby affect various DNA-templated processes, such as gene transcription, DNA replication, DNA recombination, and DNA repair in cells. These molecular processes contribute to basic cellular functions, including cell cycle, cell growth, and apoptosis. Histone modifications consist of acetylation, methylation, phosphorylation, ubiquitination, sumoylation biotination, citrullination, poly-ADPribosylation, and N-glycosylation. The modification status of histone is balanced by two enzyme families with opposing catalytic activities: histone modifying and de-modifying enzymes. Recent studies have shown that dysfunction of histone modification enzymes is a major cause for human cancer initiation and progression. In this review, we will summarize the functions of histone modification enzymes in cancer, and the mechanisms that histone modification enzymes use to drive or suppress human malignancies.

Citations

Jan 6, 2017·Cell Proliferation·Yongjing HeLi He
May 9, 2018·Thoracic Cancer·Simin LiKe-Neng Chen
Apr 6, 2019·Current Pharmaceutical Design·Veronika A MyasoedovaAlexander N Orekhov
Oct 26, 2016·Genes, Chromosomes & Cancer·Kristina Karrman, Bertil Johansson
May 28, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jingzhe ZhangWenjun Wang
Mar 27, 2019·Journal of Cellular Physiology·Shilong Ning, Xiao Ma
Aug 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hongliang YingDaliang Kong
Jul 30, 2020·Journal of Hematology & Oncology·Ran DuanWeijian Guo
Nov 12, 2020·The Science of the Total Environment·Jixiang WangRuiyan Niu
Aug 20, 2021·Frontiers in Cardiovascular Medicine·Ezra B Ketema, Gary D Lopaschuk

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