PMID: 9552384Jan 1, 1996Paper

The functions of Myc in cell cycle progression and apoptosis

Progress in Cell Cycle Research
P SteinerM Eilers

Abstract

c-myc has emerged as one of the central regulators of mammalian cell proliferation. The gene encodes a transcription factor of the HLH/leucine zipper family of proteins that activates transcription as part of a heteromeric complex with a protein termed Max. In mammalian fibroblasts, Myc acts as an upstream regulator of cyclin-dependent kinases and functionally antagonises the action of at least one cdk inhibitor, p27. Myc also induces cells to undergo apoptosis, and the relationship between Myc-induced cell cycle entry and apoptosis is discussed.

Citations

Sep 3, 2002·American Journal of Respiratory Cell and Molecular Biology·Alissa K GreenbergTheodore C Lee
Jun 23, 1999·Oncogene·D Sakamuro, G C Prendergast
Apr 18, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S M F BrennaK J Syrjanen
Mar 17, 1999·Japanese Journal of Cancer Research : Gann·H WatanabeO Niwa
May 22, 2001·Environmental Health Perspectives·W C GelderblomD Ramljak
Aug 23, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tsan-Zon LiuChi-Liang Chern
Jun 15, 2007·Biochemical and Biophysical Research Communications·Ekaterina NikolovaYves Poumay

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