The future liver of the Asia pacific: fatter and firmer from more fructose and fortune?

Journal of Clinical and Experimental Hepatology
Suzanne E Mahady, Jacob George

Abstract

The Asia Pacific region is the most diverse and the most populous region in the world. Recent socioeconomic changes have resulted in an emerging epidemic of non-communicable diseases such as type 2 diabetes and nonalcoholic fatty liver disease. The prevalence of nonalcoholic fatty liver disease in Asian Pacific countries now approximates that seen in Western countries. This increase is fueled by rising obesity, partly due to adoption of Western style diets and exposure to compounds such as high fructose corn syrup that are not included in traditional diets. Furthermore, South Asian populations may be more genetically susceptible via the inheritance of polymorphisms in apolipoprotein 3 that increase insulin resistance and nonalcoholic fatty liver disease. Importantly, there remains a substantial lack of data on the incidence and natural history of nonalcoholic steatohepatitis and subsequent complications such as hepatocellular carcinoma in Asian Pacific populations. This information gap prevents estimation of current and future disease burden and impedes efforts to lobby health policymakers to improve public health measures, as given the size of Asian Pacific populations, prevention rather than treatment of non-communicable dise...Continue Reading

Citations

Sep 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patricia C ValeryFreddie Bray
Dec 30, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Sreeshma TellapuriSanjeeva P Kalva
May 26, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Madunil A NiriellaHithanadura J de Silva
May 17, 2017·Journal of Clinical and Translational Hepatology·Sital SinghSouvik Sarkar
Mar 23, 2021·Journal of Clinical and Experimental Hepatology·Ajay DusejaMadhumita Premkumar

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