The future of biomarkers in the management of patients with acute coronary syndromes

Current Opinion in Cardiology
Michelle O'Donoghue, David A Morrow

Abstract

Biomarkers play an important role in the diagnosis and management of patients with acute coronary syndromes. The rapid growth of candidate novel markers has emphasized the need for a systematic approach to their evaluation. Several biomarkers in the past few years have been shown to be useful for risk stratification in patients with acute coronary syndromes. However, in addition to demonstrating reproducibility across large patient populations, novel markers, including high-sensitivity troponin assays, need to convincingly demonstrate their incremental utility beyond that of existing markers and should contribute toward improved patient care. Many existing biomarkers measure facets of the same disease process and are tightly correlated, thereby reducing the probability that a candidate marker will add substantial incremental discrimination for risk stratification. Unbiased approaches to identifying new markers, such as genome-wide association studies, may prove to be useful for helping in identifying genomic sequence variants, as well as protein or metabolite perturbations, which reflect novel disease-associated pathways. The number of novel biomarkers is expected to continue to grow exponentially over the next few years. Candi...Continue Reading

References

Oct 21, 1992·Molecular and Cellular Biochemistry·A H KleineG J Van der Vusse
May 15, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·J F GlatzW T Hermens
Sep 12, 2000·Circulation·A S JaffeH Katus
Aug 14, 2001·Journal of the American College of Cardiology·P A HeidenreichM A Hlatky
Jul 26, 2003·Clinical Chemistry·David A MorrowChristopher P Cannon
May 16, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Roy F M van der PuttenWim Th Hermens
Feb 28, 2007·Circulation·David A Morrow, James A de Lemos
Jul 20, 2007·American Journal of Clinical Pathology·Stacy E F MelansonPetr Jarolim
Oct 24, 2007·Circulation·Kristian ThygesenNawwar Al-Attar
Nov 21, 2007·Journal of the American College of Cardiology·James A de Lemos, Michelle O'Donoghue

❮ Previous
Next ❯

Citations

Feb 9, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Katarzyna KorybalskaJanusz Witowski
Apr 19, 2012·European Heart Journal·Lutz Philipp BreitlingHermann Brenner
Jan 1, 2009·Expert Opinion on Medical Diagnostics·Paul Anaya
Feb 22, 2012·International Journal of Cardiology·Sally J Aldous
Jan 20, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Luis C L CorreiaManoel Barral-Netto
Oct 7, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Luis C L CorreiaJ Péricles Esteves

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.