The future of regenerative therapy in patients with chronic heart failure

Nature Clinical Practice. Cardiovascular Medicine
Magdi YacoubNadia Rosenthal

Abstract

Regenerative therapy is a rapidly growing branch of science and medicine, which could have an important impact on the treatment of heart failure, a major cause of disability and death. Regeneration of the damaged myocardium in heart failure can be achieved through different strategies aimed at 'reviving' existing malfunctioning cells, repopulating the myocardium by new cells from exogenous or endogenous sources, altering the extracellular matrix, or increasing blood supply by enhancing vasculogenesis. To date, the clinical application of some of these strategies has had minimal or no impact on the global epidemic of chronic heart failure. However, several small clinical trials have reported varying degrees of functional improvement which could be considerable in some cases. We here review recent progress in the field, suggest an integrated approach, and outline the many gaps in our knowledge which need to be resolved by intensive laboratory research if regenerative therapy for chronic heart failure is to achieve its future potential.

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Citations

Jan 6, 2010·Journal of Medicinal Chemistry·Agnès I LukaszewiczMichael Kahn
Jun 23, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Puspa BattenMagdi H Yacoub
Mar 8, 2013·Future Cardiology·Satsuki FukushimaKen Suzuki
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Apr 8, 2009·Circulation·Hung Q Ly, Stanley Nattel
Sep 11, 2009·Acute Cardiac Care·Antonis A Pitsis, Aikaterini Visouli

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