The Future of Surveillance in the Context of Cancer Predisposition: Through the Murky Looking Glass

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
David MalkinGarrett M Brodeur

Abstract

At least 10% of children with cancer harbor a disease-associated pathogenic variant in a known cancer predisposition gene. It is widely accepted that pathogenic variants affecting other genes, epigenetic factors, or abnormalities in additional gene products may contribute to the etiology of many more childhood cancers. Effective preventive measures exist for only a few cancer types associated with predisposing conditions, but the development and implementation of surveillance protocols aimed at reducing morbidity and mortality in at-risk children through the early detection of cancer has emerged as an important clinical tool. The articles in this Clinical Cancer Research series present international consensus generated recommendations for surveillance for a wide spectrum of cancer predisposition syndromes affecting children. In this article, we explore the challenges and opportunities for researchers and practitioners in the many fields affiliated with pediatric cancer, and we offer insights into what the future might hold as we continue our efforts to mitigate the impact of cancer susceptibility on children, their families and society. Clin Cancer Res; 23(21); e133-e7. ©2017 AACRSee all articles in the online-only CCR Pediatri...Continue Reading

References

Sep 2, 2015·JAMA : the Journal of the American Medical Association·Rajen J ModyArul M Chinnaiyan
Nov 19, 2015·The New England Journal of Medicine·Jinghui ZhangJames R Downing
Sep 7, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Joshua M BaumlCorey J Langer
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Feb 16, 2017·Cancer Cell·Alberto Bardelli, Klaus Pantel
Mar 3, 2017·Nature Reviews. Clinical Oncology·Giulia SiravegnaAlberto Bardelli
Jun 3, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Garrett M BrodeurDavid Malkin
Jun 3, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mary-Louise C GreerLisa J States
Jun 3, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christian P KratzDavid Malkin
Jun 18, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William D FoulkesLisa Diller
Jun 18, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kris Ann P SchultzWilliam D Foulkes
Jul 5, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria Isabel AchatzSharon E Plon
Aug 18, 2017·Science Translational Medicine·Jillian PhallenVictor E Velculescu

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Citations

Dec 6, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Jack BrzezinskiJonathan D Wasserman
Jan 9, 2019·Nature Reviews. Disease Primers·Stephen X SkapekDouglas S Hawkins
Jul 26, 2019·Pediatric Blood & Cancer·Michaela KuhlenMichael C Frühwald
May 12, 2020·Pediatric Blood & Cancer·Alex Kentsis
Oct 18, 2019·Pediatric Radiology·R Paul GuillermanJohn R Priest
Dec 4, 2020·BMJ : British Medical Journal·Logan G Spector, Lazaros Kochilas
Jun 3, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Philip J Lupo, Logan G Spector
Sep 3, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roya M Mostafavi, Kim E Nichols

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