The future outlook on allergen immunotherapy in children: 2018 and beyond

Italian Journal of Pediatrics
Stefania ArasiGiovanni B Pajno

Abstract

Allergen immunotherapy (AIT) is the only currently available immune-modifying and aetiological treatment for patients suffering from IgE-mediated diseases. In childhood, it represents a suitable therapeutic option to intervene during the early phases of respiratory allergic diseases such as rhino-conjunctivitis and asthma, which is when their progression may be more easily influenced. A growing body of evidence shows that oral immunotherapy represents a promising treatment option in children with persistent IgE- mediated food allergy. The efficacy of AIT is under investigation also in patients with extrinsic atopic dermatitis, currently with controversial results. Furthermore, AIT might be a strategy to prevent the development of a new sensitization or of a (new) allergic disease. However, there are still some methodological criticisms, such as: a) the regimen of administration and the amount of the maintenance dose are both largely variable; b) the protocols of administration are not standardized; c) the description and classification of side effects is variable among studies and needs to be standardized; d) quality of life and evaluation of health economics are overall missing. All these aspects make difficult to compare each...Continue Reading

References

Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·R D GrembialeS A Marsico
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Christian MöllerUlrich Wahn
Dec 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G B PajnoG Barberio
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Elio NovembreAlberto Vierucci
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Kayhan T Nouri-AriaStephen R Durham
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Ernesto EnriqueAnna Cisteró-Bahíma
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Graham RobertsGideon Lack
Oct 6, 2006·The New England Journal of Medicine·Peter S CreticosUNKNOWN Immune Tolerance Network Group
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles PiletteStephen R Durham
Dec 26, 2007·The Journal of Allergy and Clinical Immunology·Giorgio LongoAlessandro Ventura
Aug 30, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Maurizio MarognaSalvatore Tripodi
Sep 23, 2008·Lancet·Rafea ShaabanBénédicte Leynaert
Nov 13, 2008·The Journal of Allergy and Clinical Immunology·Gabrielle PauliHans-Jorgen Malling
Nov 13, 2008·The Journal of Experimental Medicine·Flurina MeilerMübeccel Akdis
Dec 3, 2008·The Journal of Allergy and Clinical Immunology·Ulrich WahnUNKNOWN SLIT Study Group
Feb 24, 2009·The Journal of Allergy and Clinical Immunology·Teresa Boyano-MartínezSantiago Quirce
Jul 14, 2010·The Journal of Allergy and Clinical Immunology·Lara S FordScott H Sicherer
Sep 8, 2010·The Journal of Allergy and Clinical Immunology·Jan L BrozekUNKNOWN Grading of Recommendations Assessment, Development and Evaluation Working Group
Nov 9, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Giovanni Battista PajnoGiovanni Passalacqua
Feb 2, 2011·The Journal of Allergy and Clinical Immunology·Louisa K JamesStephen R Durham
Feb 2, 2011·The Journal of Allergy and Clinical Immunology·Edwin H KimA Wesley Burks
Mar 5, 2011·The Journal of Allergy and Clinical Immunology·Antonino RomanoMiguel Blanca
May 4, 2011·Allergy and Asthma Proceedings·Lawrence M DuBuskeKarl J Fischer von Weikersthal-Drachenberg
Jun 16, 2012·The Journal of Allergy and Clinical Immunology·Natalija NovakCezmi Akdis
Jul 31, 2012·The Journal of Allergy and Clinical Immunology·Laura HatzlerPaolo Maria Matricardi
Mar 5, 2013·The Journal of Allergy and Clinical Immunology·Willem van de VeenMübeccel Akdis
Jun 19, 2013·The Journal of Allergy and Clinical Immunology·Patrick G HoltPeter Sayre
Jul 23, 2013·The Journal of Allergy and Clinical Immunology·Piyush PatelBirgit Huber
Jan 7, 2014·The Journal of Allergy and Clinical Immunology·Karl-Christian BergmannRobert K Zeldin
Jan 7, 2014·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Hugh A Sampson
Mar 4, 2014·The Journal of Allergy and Clinical Immunology·Mübeccel Akdis, Cezmi A Akdis
Mar 4, 2014·The Journal of Allergy and Clinical Immunology·Désirée Larenas-LinnemannMatthias Kopp
Mar 5, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Paolo M Matricardi
May 6, 2014·The Journal of Allergy and Clinical Immunology·Giovanna StringariUNKNOWN Italian Pediatric Allergy Network (I-PAN)
Jun 10, 2014·Allergy·A MuraroUNKNOWN EAACI Food Allergy and Anaphylaxis Guidelines Group
Sep 13, 2014·The Journal of Allergy and Clinical Immunology·Mongkol Lao-ArayaMohamed H Shamji
Nov 20, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Zsolt SzépfalusiRadvan Urbanek

❮ Previous
Next ❯

Citations

Feb 17, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giovanni Battista PajnoStefania Arasi
Apr 4, 2020·Expert Opinion on Biological Therapy·Giovanni Battista PajnoGian Luigi Marseglia
Aug 19, 2020·Expert Opinion on Pharmacotherapy·Peter Valentin Tomazic, Doris Lang-Loidolt
Feb 26, 2019·Frontiers in Pediatrics·Stefania ArasiAlessandro G Fiocchi
Oct 5, 2018·Current Allergy and Asthma Reports·Antonella Muraro, Stefania Arasi
Jan 16, 2019·F1000Research·Gisela M Vaitaitis, David H Wagner
Mar 25, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·P BéginM M Goetghebeur
Oct 8, 2019·Therapeutic Advances in Respiratory Disease·Cun YouFei Wang
Mar 19, 2020·Bioscience Reports·Hiu Yan LamKwang Seok Ahn
Aug 1, 2020·Minerva pediatrica·Stefania ArasiMontserrat Alvaro-Lozano
Sep 15, 2020·Revue Française D'allergologie·F Amat, A Labbé
Mar 10, 2019·The Journal of Allergy and Clinical Immunology·Paolo Maria MatricardiHarald Renz
Jun 30, 2021·Anales De Pediatría·Mercedes Escarrer-JaumeMontserrat Álvaro-Lozano
Jun 14, 2021·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Mercedes Escarrer-JaumeMontserrat Álvaro-Lozano
Jul 27, 2021·Pharmacology Research & Perspectives·Wenjing YaoYuanyuan Xue
Oct 24, 2019·Current Pediatric Reviews·Carlo CaffarelliGiampaolo Ricci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Expert Review of Clinical Immunology
Stefania ArasiGiovanni B Pajno
Bulletin de l'Académie nationale de médecine
Pascal DemolyFrançois-Bernard Michel
Italian Journal of Pediatrics
Giovanni B PajnoAllergen-specific Immunotherapy panel of the Italian Society of Pediatric Allergy and Immunology (SIAIP)
© 2022 Meta ULC. All rights reserved