The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response

FEBS Letters
M LindemannH Grosse-Wilde

Abstract

The G protein beta3 subunit (GNB3) 825T allele is predictive of enhanced Gi protein activation. Studying the influence of C825T allele status on cellular in vitro immune responses towards recall antigens and interleukin-2 stimulation we observed a 2-4-fold, significantly increased proliferation in homozygous 825T (TT) vs. C825 allele (CC) carriers. Furthermore, lymphocyte chemotaxis and CD4(+) T cell counts of individuals with TT+TC genotypes were significantly enhanced compared to the CC genotype. In summary, it appears that C825T allele status is highly predictive of immunocompetence and could be a candidate gene in disorders associated with inadequate immune response.

References

Jan 1, 1992·Immunology Letters·A S Gukovskaya
Oct 1, 1991·European Journal of Immunology·K E Chaffin, R M Perlmutter
Dec 1, 1995·Nature Medicine·A AmadoriL Chieco-Bianchi
Aug 1, 1995·The Journal of Experimental Medicine·J G Cyster, C C Goodnow
Jan 1, 1997·The Journal of Pediatrics·I M LisseL B Christensen
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·E R Neptune, H R Bourne
Jan 13, 1998·Nature Genetics·W SiffertB Horsthemke
Feb 17, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·S WorkuD Islam
Aug 7, 1998·Tissue Antigens·I DesombereG Leroux-Roels
Nov 20, 1998·Molecular and Cellular Biology·H K Kim, G Siu
Feb 19, 1999·Annals of Surgery·M DitschkowskiH Grosse-Wilde
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·J BeigeA M Sharma
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E J GoetzlJ K Voice
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M S LombardiC J Heijnen

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Citations

Jan 18, 2003·Current Hypertension Reports·Winfried Siffert
Mar 17, 2004·Cancer Letters·Peter KripplHellmut Samonigg
Mar 6, 2003·Atherosclerosis·Nicolas von BeckerathAdnan Kastrati
Sep 11, 2003·Autoimmunity Reviews·David R Milich, Geert G Leroux-Roels
Feb 1, 2012·Molecular Psychiatry·C L Raison, A H Miller
Sep 3, 2010·Transplantation·Monika LindemannOliver Witzke
Jun 18, 2004·Kidney International·Lise ThibaudinFrançois Berthoux
Jan 22, 2005·Annual Review of Medicine·Winfried Siffert
Oct 22, 2009·Pharmacogenomics·Ibrahim A Abdel-Hamid, Karl-Erik Andersson
May 31, 2011·Pharmacogenomics·Stefanie Klenke, Winfried Siffert
Sep 3, 2011·Nuklearmedizin. Nuclear Medicine·V BarsegianM Lindemann
Jul 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M LindemannH Grosse-Wilde
Apr 25, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Monika LindemannHans Grosse-Wilde
Jun 15, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y A SaitoN J Talley
Mar 12, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N van LelyveldM Samsom
Aug 30, 2006·Acta Paediatrica·Siri Hauge OpdalTorleiv Ole Rognum
Apr 24, 2015·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Andrea SempliciniGiulio Ceolotto
Jun 20, 2013·Expert Opinion on Pharmacotherapy·Baharak MoshireeNicholas Talley
Oct 6, 2006·Expert Opinion on Pharmacotherapy·Yuri A Saito, Michael Camilleri
May 16, 2014·Gut and Liver·Hyun Ah ChungHyung Seok Park
Mar 10, 2015·Frontiers in Immunology·Linda Ferrante, Siri Hauge Opdal
Aug 25, 2004·Best Practice & Research. Clinical Gastroenterology·Gerald HoltmannWinfried Siffert
Oct 9, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Vahé BarsegianMonika Lindemann
Jul 27, 2006·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Xiangna TangAshok Kumar
Dec 14, 2004·Best Practice & Research. Clinical Gastroenterology·Gerald Holtmann
Feb 13, 2013·International Journal of Cancer. Journal International Du Cancer·Kristian W PajtlerAngelika Eggert
Sep 22, 2018·Expert Review of Clinical Immunology·Mounika AddulaDevendra K Agrawal
Feb 11, 2003·The Journal of Urology·Herbert SperlingWinfried Siffert
Jul 15, 2015·World Journal of Gastroenterology : WJG·Anastasia KourikouKonstantinos Triantafyllou

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