The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response

Proceedings of the National Academy of Sciences of the United States of America
Jennifer R PowellFrederick M Ausubel

Abstract

Innate immunity is an ancient defense system used by both vertebrates and invertebrates. Previously characterized innate immune responses in plants and animals are triggered by detection of pathogens using specific receptors, which typically use a leucine-rich repeat (LRR) domain to bind molecular patterns associated with infection. The nematode Caenorhabditis elegans uses defense pathways conserved with vertebrates; however, the mechanism by which C. elegans detects pathogens is unknown. We screened all LRR-containing transmembrane receptors in C. elegans and identified the G protein-coupled receptor FSHR-1 as an important component of the C. elegans immune response to Gram-negative and Gram-positive bacterial pathogens. FSHR-1 acts in the C. elegans intestine, the primary site of exposure to ingested pathogens. FSHR-1 signals in parallel to the known p38 MAPK pathway but converges to regulate the transcriptional induction of an overlapping but nonidentical set of antimicrobial effectors. FSHR-1 may act generally to boost the nematode immune response, or it may function as a pathogen receptor.

References

Sep 13, 2011·Archives of Microbiology·Balasubramanian VigneshkumarKrishnaswamy Balamurugan
Aug 21, 2009·Nature Immunology·François Leulier, Julien Royet
Dec 24, 2009·Nature Reviews. Immunology·J E IrazoquiFrederick M Ausubel
Jun 2, 2009·Médecine sciences : M/S·Katja Ziegler, Nathalie Pujol
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kathleen A EstesEmily R Troemel
Dec 12, 2012·Infection and Immunity·Sirena Montalvo-KatzMichael Shapira
Jun 6, 2012·CBE Life Sciences Education·Elisabeth A Cox-PaulsonJanet M Batzli
Sep 19, 2009·PLoS Genetics·Laura E FuhrmanAlejandro Aballay
Jun 22, 2012·PLoS Genetics·Read Pukkila-WorleyFrederick M Ausubel
Jul 7, 2011·PLoS Pathogens·Read Pukkila-WorleyEleftherios Mylonakis
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cheng-Gang ZouKe-Qin Zhang
Jan 13, 2016·BMC Cell Biology·Joseph D Robinson, Jennifer R Powell
Oct 4, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Chaohua Dong, Peng Zhang
Oct 6, 2010·Developmental and Comparative Immunology·Virginie Cuvillier-HotAurélie Tasiemski
Sep 9, 2009·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Akane OishiIsao Katsura
Feb 1, 2011·Cellular Microbiology·Man-Wah Tan, Michael Shapira
Feb 5, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Frederick A PartridgeJonathan Hodgkin
Jan 13, 2012·Current Opinion in Immunology·Read Pukkila-Worley, Frederick M Ausubel
Sep 24, 2013·Worm·Alexandra Anderson, Rachel McMullan
Mar 15, 2015·Frontiers in Endocrinology·Claire CahoreauYves Combarnous
Jun 6, 2016·Biochemical Pharmacology·Jerome Reboul, Jonathan J Ewbank
Nov 6, 2009·American Journal of Physiology. Cell Physiology·Tiecheng YuJianguo Liu

Citations

Aug 23, 2001·Current Biology : CB·Nathalie PujolJonathan J Ewbank
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Jul 27, 2002·Science·Dennis H KimFrederick M Ausubel
Aug 15, 2002·Current Biology : CB·Gustavo V MalloJonathan J Ewbank
Jun 21, 2003·Science·Danielle A GarsinFrederick M Ausubel
Jun 28, 2003·Methods : a Companion to Methods in Enzymology·Ravi S Kamath, Julie Ahringer
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nicole T LiberatiFrederick M Ausubel
Jun 18, 2004·Immunological Reviews·Hinrich SchulenburgJonathan J Ewbank
Jul 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dennis H KimFrederick M Ausubel
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Oct 19, 2004·Genome Research·Jean-François RualMarc Vidal
Jan 18, 2005·Current Opinion in Immunology·Dennis H Kim, Frederick M Ausubel
Jan 22, 2005·Nature·Qing R Fan, Wayne A Hendrickson
Mar 2, 2005·Trends in Microbiology·Costi D SifriFrederick M Ausubel
Jul 29, 2005·Nature·Derek SieburthJoshua M Kaplan
Apr 25, 2006·Cell·Li SunMone Zaidi
Mar 24, 2007·Nature Reviews. Immunology·Hiroshi Takayanagi
Oct 30, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Shan HerathI Martin Sheldon
Nov 3, 2007·EMBO Reports·Jennifer L Tenor, Alejandro Aballay

Related Concepts

Vertebrates
Gram-Positive Bacteria
Calcinus elegans
Cyartonema elegans
Coleonyx elegans
Immune Response
Biochemical Pathway
Cestrum elegans
Clarkia unguiculata
Clathrulina elegans

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