The GABA-A beta3 subunit mediates anaesthesia induced by etomidate

Neuroreport
G F O'MearaD S Reynolds

Abstract

The i.v. agent etomidate exerts its anaesthetic actions through potentiation of gamma-aminobutyric acid-A receptors containing beta2 and beta3 subunits. It was recently shown that the beta2 subunit contributes to the sedative properties of etomidate, whereas the beta3 subunit is responsible for its anaesthetic properties. However, these studies evaluated anaesthetic effects in point mutation mice in which the effect of etomidate was decreased, but not abolished, at the beta2 subunit. Here we have used beta2 knockout mice to completely remove any contribution of the beta2 subunit to the effects of etomidate. Etomidate was equally anaesthetic in wildtype and knockout mice, thus further confirming that efficacy at the beta3 subunit only is sufficient to induce general anaesthesia.

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Citations

Oct 22, 2008·Anesthesia and Analgesia·Logan J VossHeidi E Kirsch
Jul 11, 2006·Current Opinion in Anaesthesiology·Gavin J Kilpatrick, Gary S Tilbrook
Jun 1, 2012·Expert Opinion on Drug Discovery·Matthew D Krasowski, Anton J Hopfinger
Sep 29, 2004·Biochemical Pharmacology·Stephen L BoehmR Adron Harris
Jul 6, 2010·European Journal of Pharmacology·Logan J VossJames W Sleigh
Aug 3, 2006·The European Journal of Neuroscience·James O GrovesDavid S Reynolds
Jan 12, 2007·Journal of Neurophysiology·Kim Ryun DrasbekKimmo Jensen
Apr 10, 2021·BMC Anesthesiology·Lei ZhangErwei Gu

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