journal cover

The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism

Cell Metabolism

Mar 5, 2015

Arnaud BessePenelope E Bonnen

Abstract

ABAT is a key enzyme responsible for catabolism of principal inhibitory neurotransmitter γ-aminobutyric acid (GABA). We report an essential role for ABAT in a seemingly unrelated pathway, mitochondrial nucleoside salvage, and demonstrate that mutations in this enzyme cause an autosomal ...read more

Mentioned in this Paper

ABAT gene
ALDH5A1 gene
DGUOK gene
GAPDH gene
NME4 gene
SUCLA2 gene
SUCLG1 gene
SUCLG2 gene
TRIM8 gene
Co-Immunoprecipitation
4
1
1
55
Paper Details
References
  • References35
  • Citations21
1234
  • References35
  • Citations21
123

Similar Papers Found In These Feeds

Computation Neuroscience

Computation neuroscience employs models, statistics, simulations, and theoretical analyses to understand mechanisms that govern neural functions. Here is the latest research in this domain.

Neurotransmitters

Neurotransmitters are released from synaptic vesicles in presynaptic neurons in response to neural activity, diffuse across the synaptic cleft, and bind specific receptors in order to bring about changes in postsynaptic neurons. Here is the latest research.

Hearing loss: Bioengineering

More than 300 million people around the world suffer from disabling hearing loss. Here is the latest research on bioengineering solutions for this problem.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Neonatal Seizures

Neonatal seizures are the most common neurological emergency in the neonatal period and are associated with a poor long-term outcome. Discover the latest research on neonatal seizures here.

Membrane Transport in Heart Failure

This feed focuses on Membrane Transport proteins and their dysfunction which can lead to heart disease. Discover the latest research on Membrane Transport in Heart Failure.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Electron Transport Chain Biology

The electron transport chain (ETC) facilitates the transfer of electrons through redox while transferring protons across the membrane into the intermembrane space. This feed focuses on the structure and mechanism of the ETC as well as mitochondrial disorders caused by defects in the oxidative phosphorylation pathway.

Neurodevelopmental disorder

Neurodevelopmental disorders such as attention deficit hyperactivity disorder (adhd) and autism spectrum disorder, although most commonly considered in childhood, can be lifelong conditions. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Congenital Brain Malformations

Congenital brain malformations are a major cause of morbidity and mortality in pediatric patients younger than 2 years. Discover the latest research on congenital brain malformations here.

Lymphopenia

Lymphopenia has been associated with autoimmune pathology and it has been suggested that lymphopenia-induced proliferation of naive T cells may be responsible for the development of immune pathology. Here is the latest research.


HDACs in Obesity

Histone deacetylases (HDACs) are key epigenetic regulators of metabolic homeostasis. Here is the latest research on HDACs in obesity.

Mitochondrial Metabolism

Mitochondrial metabolism links energy production to other essential cellular processes such as signaling, cellular differentiation, and apoptosis. Discover the latest research here.

Corticobasal Degeneration

Corticobasal Degeneration (CBD)is a rare, neurodegenerative disease of the cerebral cortex and the basal ganglia, characterized by movement disorders. Discover the latest research on CBD here.

Retinal Degeneration: Mitochondria

The feed focuses on the role of defective mitochondria and their early role in promoting retinal degeneration.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

Retinal Development: Genetics

This feed focuses on genetic, epigenetic, and transcriptomic processes pertaining to retinal development and aging.

Muscle Mitochondrial Networks

This feed focuses on the role of mitochondrial networks and energy metabolism in muscle cells. Discover the latest research here.

Drug-Induced Diseases

Drug-induced diseases (DID) also called as iatrogenic diseases. Most of these DIDs are largely preventable, if strict vigilance and proper periodic clinical and diagnostic monitoring are undertaken

Retinal Development And Aging: Genetics

This feed focuses on genetic, epigenetic, and transcriptomic processes pertaining to retinal development and aging. Here is the latest research.

Movement Disorders

Movement disorders are a group of nervous system disorders that increase or decrease voluntary or involuntary movements. Here is the latest research on genetic and environmental factors, as well as mechanisms that underlie movement disorders.

Neurocognition and Behaviour

This feed focuses on neurobehavioral manifestations, neurocognitive development, and cognition disorders. Here is the latest research.

© 2020 Meta ULC. All rights reserved

The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism

Cell Metabolism

Mar 5, 2015

Arnaud BessePenelope E Bonnen

PMID: 25738457

DOI: 10.1016/j.cmet.2015.02.008

Abstract

ABAT is a key enzyme responsible for catabolism of principal inhibitory neurotransmitter γ-aminobutyric acid (GABA). We report an essential role for ABAT in a seemingly unrelated pathway, mitochondrial nucleoside salvage, and demonstrate that mutations in this enzyme cause an autosomal ...read more

Mentioned in this Paper

ABAT gene
ALDH5A1 gene
DGUOK gene
GAPDH gene
NME4 gene
SUCLA2 gene
SUCLG1 gene
SUCLG2 gene
TRIM8 gene
Co-Immunoprecipitation
4
1
1
55

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References35
  • Citations21
1234
  • References35
  • Citations21
123
/papers/the-gaba-transaminase-abat-is-essential-for/25738457