The GABA(A) agonist gaboxadol improves the quality of post-nap sleep

Psychopharmacology
S MathiasM Lancel

Abstract

Previous studies demonstrated that gaboxadol, a selective GABA(A) agonist, increases both non-REM sleep and EEG delta activity within non-REM sleep in rats and slow wave sleep (SWS) as well as low-frequency activity in the EEG within non-REM sleep in healthy humans under normal conditions. Because the hypnotic actions of drugs may be more readily demonstrated under conditions of poor sleep quality, we investigated the influence of gaboxadol on postnap sleep. In a randomized, placebo-controlled cross-over study using a late afternoon nap model, we assessed the effects of a single oral dose of 20 mg gaboxadol on disturbed nighttime sleep in young, healthy subjects. Comparisons of visually scored sleep parameters between baseline and placebo postnap nights showed that the nap prolonged sleep latency, decreased total sleep time and SWS and attenuated delta, theta and alpha activity in the EEG within non-REM sleep. Compared with the placebo postnap night, gaboxadol tended to shorten sleep latency, significantly decreased intermittent wakefulness, increased total sleep time and SWS and enhanced delta and theta activity in the non-REM EEG. Furthermore, gaboxadol increased subjective sleep quality. These data show that gaboxadol counte...Continue Reading

Citations

Apr 9, 2005·Neuropharmacology·Vladyslav V VyazovskiyIrene Tobler
Apr 23, 2003·European Journal of Pharmacology·Signe í Stórustovu, Bjarke Ebert
Dec 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefan MathiasMarike Lancel
Oct 18, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Junshui MaSteve Deacon
Nov 6, 2013·Pharmacology & Therapeutics·M DreslerF Holsboer
May 29, 2009·The European Journal of Neuroscience·Raphaëlle Winsky-Sommerer
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Aug 4, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thierno M BahJeffrey J Iliff

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