The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats

Frontiers in Aging Neuroscience
B Blair BradenHeather A Bimonte-Nelson

Abstract

In women, high levels of natural progesterone have been associated with detrimental cognitive effects via the "maternal amnesia" phenomenon as well as in controlled experiments. In aged ovariectomized (Ovx) rats, progesterone has been shown to impair cognition and impact the GABAergic system in cognitive brain regions. Here, we tested whether the GABAergic system is a mechanism of progesterone's detrimental cognitive effects in the Ovx rat by attempting to reverse progesterone-induced impairments via concomitant treatment with the GABAA antagonist, bicuculline. Thirteen month old rats received Ovx plus daily vehicle, progesterone, bicuculline, or progesterone+bicuculline injections beginning 2 weeks prior to testing. The water radial-arm maze was used to evaluate spatial working and reference memory. During learning, rats administered progesterone made more working memory errors than those administered vehicle, and this impairment was reversed by the addition of bicuculline. The progesterone impairment was transient and all animals performed similarly by the end of regular testing. On the last day of testing, a 6 hour delay was administered to evaluate memory retention. Progesterone-treated rats were the only group to increase ...Continue Reading

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Citations

Aug 21, 2020·Behavioural Pharmacology·Joel Hassell, Sharmin Maswood
Oct 30, 2020·Frontiers in Endocrinology·Emese RenczésPeter Celec
May 13, 2021·Climacteric : the Journal of the International Menopause Society·H A Bimonte-NelsonS V Koebele

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