PMID: 8970817Sep 15, 1996Paper

The GABA/GAD innervation within the inner spiral bundle in the mouse cochlea

Hearing Research
L M Nitecka, H M Sobkowicz

Abstract

Stains with antibodies to glutamic acid decarboxylase (GAD) and gamma-aminobutyric acid (GABA) in the cochlea of postnatal and adult mice reveal within the inner spiral bundle a distinctive neuronal plexus intimately associated with the inner hair cells. This innervation provides endings that cradle the receptor poles of the sensory cells and lateral end collaterals that wind between the cells, distributing endings alongside and around them. Some GAD-positive fibers enter the inner pillar bundle, from where they distribute tunnel fibers to the outer hair cells and recurrent collaterals to the inner hair cells. The GABAergic innervation within the inner spiral bundle is present along the entire cochlear axis, with the highest density in its basal half. Stainings against calcitonin gene-related peptide (CGRP), which localizes in the cholinergic counterpart of the inner spiral bundle, reveal that some of these fibers parallel the GABAergic circuit. The present data, together with our previous demonstration of compound (serial, converging, triadic) efferent synapses within this pathway (Sobkowicz et al. (1995) Abst. ARO 18, 171) evidences the presence of a distinctive innervation to the inner hair cells, hitherto unrecognized. The ...Continue Reading

References

Jul 1, 1975·The Annals of Otology, Rhinology, and Laryngology·C A Smith
Nov 1, 1975·Acta Oto-laryngologica·C G Wright, R E Preston
Sep 7, 1979·Brain Research·W B Warr, J J Guinan
Sep 15, 1975·The Journal of Comparative Neurology·R E Perkins, D K Morest
Dec 1, 1992·Hearing Research·D Felix, K Ehrenberger
Jan 1, 1991·Synapse·D E VetterE Mugnaini
Sep 11, 1991·Hearing Research·J L WilsonO W Henson
Jan 1, 1989·Annual Review of Neuroscience·J H Skene
Aug 1, 1989·Journal of Neurocytology·D S Whitlon, H M Sobkowicz
Apr 1, 1989·Journal of Neurocytology·H M Sobkowicz, M R Emmerling
Jan 1, 1988·Hearing Research·D W SchwarzS R Vincent
Jan 1, 1985·Behavioral and Neural Biology·A Routtenberg, D M Lovinger
Sep 15, 1988·Hearing Research·J P Campbell, M M Henson
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R L NeveL I Benowitz
Apr 8, 1987·The Journal of Comparative Neurology·R C Roberts, C E Ribak
Jun 8, 1987·The Journal of Comparative Neurology·J K Moore, R Y Moore
Jun 22, 1987·The Journal of Comparative Neurology·M C Brown
Jun 2, 1972·Science·J L Barker, R A Nicoll
Feb 1, 1969·Acta Oto-laryngologica·H Spoendlin
Sep 10, 1983·The Journal of Comparative Neurology·J S White, W B Warr
May 1, 1983·Hearing Research·R D Ginzberg, D K Morest
Jul 9, 1982·Science·N Y KiangD K Ryugo
Jul 1, 1993·Acta Physiologica Scandinavica·M UlfendahlE Theodorsson
Jan 1, 1994·Brain Research. Brain Research Reviews·J A Angulo, B S McEwen
Nov 1, 1993·Brain Research. Molecular Brain Research·G D Mower, K M Rosen
Aug 1, 1953·The Journal of Comparative Neurology·G L RASMUSSEN
Dec 1, 1951·The Laryngoscope·C FERNANDEZ

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Citations

Oct 18, 2008·Journal of the Association for Research in Otolaryngology : JARO·Stéphane F MaisonM Charles Liberman
May 1, 1997·Brain Research. Molecular Brain Research·M J DrescherD G Drescher
Jul 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D S Whitlon, X Zhang
Aug 23, 2002·Journal of Chemical Neuroanatomy·Juman Raji-KubbaDwayne D Simmons
Jan 20, 1997·The Journal of Comparative Neurology·H M SobkowiczB K August
Jul 12, 2002·Synapse·Hanna M SobkowiczBenjamin K August
Oct 17, 2002·Journal of Neurobiology·Dwayne D Simmons
Jun 11, 2021·Hearing Research·Siân R KitcherCatherine J C Weisz

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