PMID: 9182240Feb 1, 1996Paper

The gamma subunits of the native GABAA/benzodiazepine receptors

Neurochemical Research
Z U KhanA L De Blas

Abstract

Subunit-specific antibodies to all the gamma subunit isoforms described in mammalian brain (gamma(1), gamma(2S), gamma(2L), and gamma(3) have been made. The proportion of GABA(A) receptors containing each gamma subunit isoform in various brain regions has been determined by quantitative immunoprecipitation. In all tested regions of the rat brain, the gamma(1) and gamma(3) subunits are present in considerable smaller proportion of GABA(A) receptor than the gamma(2) subunit. Immunocytochemistry shows that gamma(1) immunoreactivity concentrates in the stratum oriens and stratum radiatum of the CA1 region of the hippocampus. In the dentate gyrus, gamma(1) immunoreactivity concentrates on the outer 2/3 of the molecular layer coinciding with the localization of the axospinous synapses of the perforant pathway. In contrast, gamma(3) immunoreactivity concentrates on the basket cells and other GABAergic local circuit neurons of the hilus. These cells are also rich in gamma(2S). In the cerebellum, gamma(1)++ immunolabeling was localized on the Bergmann glia. The gamma(2S) and gamma(2L) subunits are differentially expressed in various brain regions. Thus the gamma(2S) is highly expressed in the olfactory bulb and hippocampus whereas the g...Continue Reading

References

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Jan 1, 1996·Brain Research. Molecular Brain Research·A GutiérrezA L De Blas

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Citations

Jul 22, 1998·Progress in Neurobiology·C L FaingoldA Riaz
Nov 7, 2002·Anatomical Science International·Keiko Yamada, Masahiko Watanabe
Aug 16, 2000·The Journal of Physiology·M LorezJ A Benson
Feb 1, 1996·Molecular Neurobiology·A L De Blas
Mar 11, 2011·Journal of Neurochemistry·Robert A Rissman, William C Mobley
Nov 5, 2005·Neuroscience Letters·Masahiko IwakiriTakashi Asada

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