PMID: 6104751Jun 1, 1980

The ganglion-blocked, angiotensin II-supported rat: a model for demonstrating antihypertensive vasodilator activity

Journal of Pharmacological Methods
D DeitchmanR L Stratman

Abstract

This report describes the implementation of an in vivo method for demonstrating direct vasodilator activity of potential antihypertensive agents. The experimental model is an anesthetized, ganglion-blocked rat whose blood pressure is maintained by an intravenous infusion of angiotensin II. A hypotensive response in this model appears to correlate more closely with antihypertensive activity in desoxycorticosterone acetate (DOCA)-salt hypertensive rats than does a vasodilator response in the pump-perfused hind limb of anesthetized dogs. Furthermore, it distinguishes between vasodilators that are effective in hypertension, eg hydralazine and diazoxide, and vasodilators that are used to treat peripheral vascular disease, eg cinnarizine and papaverine.

References

Jul 1, 1977·British Journal of Pharmacology·R E BuckinghamD Robson
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·M A CommaratoH R Kaplan
Jul 1, 1975·Clinical and Experimental Pharmacology & Physiology·A J WoodF O Simpson
Nov 1, 1970·British Journal of Pharmacology·A M Barrett, J Carter
Jun 1, 1974·Archives of Internal Medicine·J Koch-Weser
Jan 1, 1972·European Journal of Pharmacology·J M Van Nueten, P A Janssen

Citations

Sep 2, 1983·European Journal of Pharmacology·N L Brown, M Worcel
Jan 1, 1986·General Pharmacology·R C HansonD Deitchman
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·S Subramanian, R R Vollmer
Mar 20, 2012·Protein & Cell·Hao YeYixue Li
Oct 1, 1984·Journal of Psychoactive Drugs·R E Miller
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C CicalaG Cirino

Related Concepts

Angiotensin II, Val(5)-
Metazoa
Antihypertensive Agents
Diastolic Blood Pressure
Ganglionic Blockers
Hindlimb
Hypertensive Disease
Regional Blood Flow
Vascular Endothelium-Dependent Relaxation
Rats, Laboratory

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